Evidence map›Paper›PMID 34733402›Full record

ArticleOxidative medicine and cellular longevity2021

Lifestyle-Induced Redox-Sensitive Alterations: Cross-Talk among the RAAS, Antioxidant/Inflammatory Status, and Hypertension.

Renáta Szabó, Denise Börzsei, Alexandra Hoffmann, Zelma Nadin Lesi, Rudolf Gesztelyi, Béla Juhász, Gábor J Szebeni, Jasmin Osman, Judith Sebestyén, Arnold Nagy and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Renáta SzabóDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.ORCID https://orcid.org/0000-0001-7881-2082
Denise BörzseiDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.ORCID https://orcid.org/0000-0002-7899-9374
Alexandra HoffmannDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.ORCID https://orcid.org/0000-0001-8775-4224
Zelma Nadin LesiDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.
Rudolf GesztelyiDepartment of Pharmacology and Pharmacotherapy, University of Debrecen, H-4032 Debrecen, Hungary.ORCID https://orcid.org/0000-0001-7911-055X
Béla JuhászDepartment of Pharmacology and Pharmacotherapy, University of Debrecen, H-4032 Debrecen, Hungary.ORCID https://orcid.org/0000-0001-8878-5153
Gábor J SzebeniDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.ORCID https://orcid.org/0000-0002-6998-5632
Jasmin OsmanDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.
Judith SebestyénSouth-Pest Hospital Centre, National Institute for Infectology and Haematology, Department of Burns and Plastic Surgery, Budapest H-1097, Hungary.
Arnold NagyDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.
Sándor SzegediDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.
Csaba VargaDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.ORCID https://orcid.org/0000-0002-2678-665X
Anikó PósaDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.ORCID https://orcid.org/0000-0003-2167-2888
University of Szeged · HUUniversity of Debrecen · HUNational Center for Epidemiology · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development and progression of hypertension are closely linked to an unhealthy lifestyle; however, its underlying mechanisms are not fully elucidated. Our aim was to assess the effects of diet and exercise on the elements of the renin-angiotensin-aldosterone system (RAAS), redox-sensitive parameters, and the expression of the vascular tone regulator endothelial nitric oxide synthase (eNOS). Male control Wistar-Kyoto (WKY) and stroke-prone spontaneously hypertensive (SHRSP) rats were randomized based on the type of diet (standard chow, high-fat diet: HT, and fructose-enriched diet: HF) and exercise (voluntary wheel-running exercise or lack of exercise). After 12 weeks of experimental period, the concentrations of the RAAS elements, myeloperoxidase (MPO) activity, tumor necrosis factor alpha (TNF-

Indexed as

Blood PressureLife StyleRenin-Angiotensin SystemAnimalsAntioxidantsHypertensionInflammationMaleNitric Oxide Synthase Type IIIRatsRats, Inbred SHRRats, Inbred WKYAntioxidantsNitric Oxide Synthase Type III

Identifiers

PMID34733402
PMCPMC8560269
OpenAlexW3210953110

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.