ArticleClinical practice and epidemiology in mental health : CP & EMH2021
Moderate Exercise Improves Cognitive Function in Healthy Elderly People: Results of a Randomized Controlled Trial.
Article in Clinical practice and epidemiology in mental health : CP & EMH, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Optimal type and dose of exercise for improving executive functions in older adults: a systematic review and Bayesian model-based network meta-analysis of RCTs.BMC geriatrics · 2026Pooled it
- Fully Immersive Virtual Reality-Based Cognitive Remediation for Adults with Psychosocial Disabilities: A Systematic Scoping Review of Methods Intervention Gaps and Meta-Analysis of Published Effectiveness Studies.International journal of environmental research and public health · 2023Pooled it
- Positive impact of social relationships fostered by physical and/or cognitive group activity on older people's quality of life: PRISMA systematic review.Frontiers in psychology · 2023Pooled it
- A Body-Driven Mind: Effects of Conventional and Non-Immersive Virtual Reality-Based Physiotherapy on Cognitive Function in Older Orthopedic Patients.Clinical interventions in aging · 2026Trial
- Enhancing Driving Ability in Older Adults through Health Exercises and Physical Activity: A Randomized Controlled Trial.International journal of environmental research and public health · 2023Trial
- Effect of a Low-Moderate Exercise Program on Dysmetabolism in Older Adults: Results of a Randomized Controlled Trial.Nutrients · 2022Trial
- Stress Response During a Three-Month Follow-Up of a Historical Cohort of People with Cancer: Subjective Hyper-Energy and the DYMERS Framework for a Future Preventive Approach.Journal of clinical medicine · 2026Article
- Article
- Social Rhythms, Depressive Symptoms, and Quality of Life: An Unbreakable Bond in an Older Adult Sample.International journal of environmental research and public health · 2026Observational
- Enhancing Cognitive Functions in Older Adults With Mild Cognitive Impairment via Virtual Sail 3D: Protocol for a Feasibility Randomized Controlled Trial.JMIR research protocols · 2026Article
- Studying exercise-induced affect in older adults: how the circumplex model could enhance theoretical and practical advances in the field.Frontiers in aging · 2026Article
- Bipolar disorder in an evolutionary framework: rethinking adaptation, vulnerability, and stigma.Frontiers in psychiatry · 2026Article
- Cognitive decline in U.S. military veterans: risk factors and clinical implications.Frontiers in dementia · 2026Article
- The role of hypothyroidism in the resilience against depressive episodes during covid pandemic in a cohort of old adults.Frontiers in psychiatry · 2026Article
- Exercise attenuates the hallmarks of aging: Novel perspectives.Journal of sport and health science · 2025Review
- Oral Microbiota Taxa and Pri-miRNA Expression in Bipolar Disorder: A Case-Control Study.Biomolecules · 2025Article
- An Evolutionary Preamble Towards a Multilevel Framework to Understand Adolescent Mental Health: An International Delphi Study.Children (Basel, Switzerland) · 2025Review
- Functional Foods in Clinical Trials and Future Research Directions.Foods (Basel, Switzerland) · 2025Review
- The Use of Heart Rate Variability-Biofeedback (HRV-BF) as an Adjunctive Intervention in Chronic Fatigue Syndrome (CSF/ME) in Long COVID: Results of a Phase II Controlled Feasibility Trial.Journal of clinical medicine · 2025Article
- Impact of Pre-lockdown Hyper-energy on Mood and Rhythm Dysregulation in Older Adults During the COVID-19 Pandemic.Clinical practice and epidemiology in mental health : CP & EMH · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
41 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhysical activity in the elderly is recommended by international guidelines to protect against cognitive decline and functional impairment.
objectiveThis Randomized Controlled Trial (RCT) was set up to verify whether medium-intensity physical activity in elderly people living in the community is effective in improving cognitive performance.
designRCT with parallel and balanced large groups.
settingAcademic university hospital and Olympic gyms. SUBJECTS: People aged 65 years old and older of both genders living at home holding a medical certificate for suitability in non-competitive physical activity.
methodsParticipants were randomized to a 12-week, 3 sessions per week moderate physical activity program or to a control condition focused on cultural and recreational activities in groups of the same size and timing as the active intervention group. The active phase integrated a mixture of aerobic and anaerobic exercises, including drills of "life movements", strength and balance. The primary outcome was: any change in Addenbrooke's Cognitive Examination Revised (ACE-R) and its subscales.
resultsAt the end of the trial, 52 people completed the active intervention, and 53 people completed the control condition. People in the active intervention improved on the ACE-R (ANOVA: F(1;102)=4.32, p=0.040), and also showed better performances on the memory (F(1;102)=5.40 p=0.022) and visual-space skills subscales of the ACE-R (F(1;102)=4.09 p=0.046).
conclusionA moderate-intensity exercise administered for a relatively short period of 12 weeks is capable of improving cognitive performance in a sample of elderly people who live independently in their homes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.