ReviewFrontiers in neurology2021
Retinal Vein Changes as a Biomarker to Guide Diagnosis and Management of Elevated Intracranial Pressure.
Review in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 14 citations in OpenAlex.
- Automated Retinal Vascular Analysis Reveals Response to Acetazolamide in Idiopathic Intracranial Hypertension.Translational vision science & technology · 2025Trial
- Diagnosis of High Intracranial Pressure by Non-Optic Nerve Retinal Image Features.Translational vision science & technology · 2026Article
- WAVY OBLONG RETROGRADE MOVING SEGMENTS (WORMS) INTRAVENOUS FLUORESCEIN ANGIOGRAPHIC FINDING IN A NEONATE WITH RETINOPATHY OF PREMATURITY.Retinal cases & brief reports · 2026Article
- Non-invasive fundoscopy as a tool to estimate intracranial pressure: a large animal model.Acta neurochirurgica · 2025Article
- Comparative analysis of retinal vascular structural parameters in populations with different glucose metabolism status based on color fundus photography and artificial intelligence.Frontiers in cell and developmental biology · 2025Article
- Intracranial pressure affects retinal venular complexity in idiopathic intracranial hypertension: a retrospective observational study.BMC neurology · 2024Observational
- Atypical Terson syndrome after subarachnoid hemorrhage from middle cerebral artery aneurysm rupture during coitus.Surgical neurology international · 2024Article
- Non-invasive assessment of intracranial pressure through the eyes: current developments, limitations, and future directions.Frontiers in neurology · 2024Review
- Autonomous assessment of spontaneous retinal venous pulsations in fundus videos using a deep learning framework.Scientific reports · 2023Article
- Non-Invasive Intracranial Pressure Monitoring.Journal of clinical medicine · 2023Review
- Effect of intracranial pressure on photoplethysmographic waveform in different cerebral perfusion territories: A computational study.Frontiers in physiology · 2023Article
- A Review of the Methods of Non-Invasive Assessment of Intracranial Pressure through Ocular Measurement.Bioengineering (Basel, Switzerland) · 2022Review
- A machine learning approach in the non-invasive prediction of intracranial pressure using Modified Photoplethysmography.PloS one · 2022Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Retinal vein changes, which can be observed on clinical exam or ophthalmic imaging, are promising non-invasive biomarkers for elevated intracranial pressure (ICP) as a complement to other markers of high ICP including optic nerve head swelling. Animal and human studies have demonstrated increase in retinal vein pressure associated with elevated ICP mediated by increase in cerebral venous pressure, compression of venous outflow by elevated cerebral spinal fluid pressure in the optic nerve sheath, and compression of venous outflow by optic nerve head swelling. Retinal vein pressure can be estimated using ophthalmodynamometry. Correlates of retinal vein pressure include spontaneous retinal venous pulsations, retinal vein diameter, and retinal vein tortuosity. All of these have potential for clinical use to diagnose and monitor elevated ICP. Challenges include diagnostic prediction based on single clinical measurements and accurate assessment of retinal vein parameters in cases where optic nerve head swelling limits visualization of the retinal veins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.