ArticleNature2021
B cell-derived GABA elicits IL-10
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 292 papers.
0numbers the graph read from it
0cells of the map it votes in
292citing papers in PubMed
25.8field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
292 citing papers in PubMed, 414 citations in OpenAlex.
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- Neuro-immune interactions in tumors, immune-related disorders, and infections.Signal transduction and targeted therapy · 2026Review
- SLAMF6 Enhances the Efficacy of Anti-PD-L1 Immunotherapy in CRC Through the STAT1/CXCL10 Signaling Axis.Cancer science · 2026Article
- Neural-tumor interactions: bidirectional regulatory mechanisms and nervous system-targeted tumor therapeutic strategies.Biomarker research · 2026Review
- B Cells and Tumor Immunometabolism: Emerging Insights into Immune Regulation and Therapeutic Resistance.Antibodies (Basel, Switzerland) · 2026Review
- B cells in cancer: functions, mechanisms and therapeutic advances.Signal transduction and targeted therapy · 2026Review
- The CAGE Framework (Calcium-Gated Excitability): From Single Neurotransmitters to Calcium States in the Tumor Microenvironment.International journal of molecular sciences · 2026Review
- Targeting the nervous system: Mechanistic insights into neuro-tumor communication and therapeutic opportunities.Acta pharmaceutica Sinica. B · 2026Review
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- Peripheral GABA Signaling in Metabolic Adaptation and Maladaptation.International journal of molecular sciences · 2026Review
- Neural regulation of tumor immunity: emerging opportunities to enhance cancer immunotherapy.Experimental & molecular medicine · 2026Review
- Endogenous metabolite signaling orchestrates tumor immune evasion.Cell insight · 2026Review
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- B Cell Deficiency Impairs Collateral Artery Growth by Influencing Early and Late Regenerative Inflammation.Cells · 2026Article
- Supplementation of γ-Aminobutyric Acid as a Functional Nutrient.Nutrients · 2026Review
- Integrated Elementomics-Genomics-Metabolomics Analysis Reveals Plasma Biomarker Networks and Diagnostic Potential for Gastric Cancer.Metabolites · 2026Article
- Integrated Metabolomic and Transcriptomic Profiling Reveals a Distinct Pathological Aging State in Diminished Ovarian Reserve of Advanced Reproductive-Age Women.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- GABA signaling activation drives glioblastoma progression in female mice through myeloid-derived suppressor cells.Nature cancer · 2026Article
232 more citing papers are in PubMed but not listed here.
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Authors and funding
30 authors at 5 institutions in 1 country.
Baihao ZhangLaboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan.
Alexis Vogelzang *Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan.
Michio Miyajima *Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan.
Yuki Sugiura *Department of Biochemistry and Integrative Biology, Keio University, Tokyo, Japan.
Yibo WuYCI Laboratory for Next-Generation Proteomics, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan.
Kenji ChamotoCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Rei NakanoLaboratory of Veterinary Biochemistry, Department of Veterinary Medicine, Nihon University College of Bioresource Sciences, Fujisawa, Japan.
Ryusuke HataeCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Rosemary J MenziesCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kazuhiro SonomuraCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Nozomi HojoLaboratory for Prediction of Cell Systems Dynamics, RIKEN Center for Biosystems Dynamics Research (BDR), Osaka, Japan.
Taisaku OgawaLaboratory for Prediction of Cell Systems Dynamics, RIKEN Center for Biosystems Dynamics Research (BDR), Osaka, Japan.
Wakana KobayashiLaboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan.
Yumi TsutsuiLaboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan.
Sachiko YamamotoLaboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan.
Mikako MaruyaLaboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan.
Seiko NarushimaLaboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan.
Keiichiro SuzukiLaboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan.
Hiroshi SugiyaLaboratory of Veterinary Biochemistry, Department of Veterinary Medicine, Nihon University College of Bioresource Sciences, Fujisawa, Japan.
Kosaku MurakamiDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Motomu HashimotoDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hideki UenoDepartment of Immunology, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Takashi KobayashiDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Katsuhiro ItoCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Tomoko HiranoCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Katsuyuki ShiroguchiLaboratory for Prediction of Cell Systems Dynamics, RIKEN Center for Biosystems Dynamics Research (BDR), Osaka, Japan.
Fumihiko MatsudaCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Makoto SuematsuDepartment of Biochemistry and Integrative Biology, Keio University, Tokyo, Japan.
Tasuku HonjoCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Sidonia FagarasanLaboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan. sidonia.fagarasan@riken.jp.ORCID http://orcid.org/0000-0003-2086-6402
Kyoto University · JPRIKEN Center for Integrative Medical Sciences · JPRIKEN Center for Biosystems Dynamics Research · JPKeio University · JPNihon University · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small, soluble metabolites not only are essential intermediates in intracellular biochemical processes, but can also influence neighbouring cells when released into the extracellular milieu
Indexed as
AnimalsB-LymphocytesCD8-Positive T-LymphocytesCell ProliferationFemalegamma-Aminobutyric AcidGene DeletionGlutamate DecarboxylaseHumansInflammationInterleukin-10MacrophagesMaleMiceNeoplasmsT-Lymphocytes, Cytotoxicgamma-Aminobutyric AcidGlutamate Decarboxylaseglutamate decarboxylase 1IL10 protein, humanInterleukin-10
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.