Evidence map›Paper›PMID 34732888›Full record

ArticleNature2021

Striatal indirect pathway mediates exploration via collicular competition.

Jaeeon Lee, Bernardo L Sabatini

Abstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Superior Colliculus Projections Drive Dopamine Neuron Activity and Movement But Not Value.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jaeeon LeeHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Bernardo L SabatiniHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA, USA. bsabatini@hms.harvard.edu.ORCID http://orcid.org/0000-0003-0095-9177

Funding

Towards a Unified Framework for Dopamine Signaling in the StriatumU19NS113201 · NINDS · HARVARD MEDICAL SCHOOL · PI WILBRECHT, LINDA E · 2019 to 2023
$18.7M
Super-Resolution ImagingP30NS072030 · NINDS · HARVARD MEDICAL SCHOOL · PI REGEHR, WADE G · 2011 to 2020
$5.8M
Structure and function of the mouse parafasicular and entopeduncular nucleiR01NS103226 · NINDS · HARVARD MEDICAL SCHOOL · PI OSTEN, PAVEL, SABATINI, BERNARDO L · 2017 to 2021
$2.1M
NINDS NIH HHS P30 NS072030NINDS NIH HHS R01 NS103226NINDS NIH HHS U19 NS113201
6 · The paper itself

Abstract

The ability to suppress actions that lead to a negative outcome and explore alternative actions is necessary for optimal decision making. Although the basal ganglia have been implicated in these processes

Indexed as

AnimalsBasal GangliaBehavior, AnimalCorpus StriatumDecision MakingExploratory BehaviorFemaleMaleMiceNeural InhibitionNeural PathwaysNeuronsOptogeneticsRewardSuperior Colliculi

Identifiers

PMID34732888
PMCPMC10281058

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.