Evidence map›Paper›PMID 34732874›Full record

ReviewNature reviews. Microbiology2022

Physical properties of the bacterial outer membrane.

Jiawei Sun, Steven T Rutherford, Thomas J Silhavy, Kerwyn Casey Huang

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 190 papers.

0numbers the graph read from it
0cells of the map it votes in
190citing papers in PubMed
35.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

190 citing papers in PubMed, 366 citations in OpenAlex.

  1. Review
  2. The mycomembrane proteins PorH and ProtX are inserted at polar growth zones and linked to the cell wall.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. LPS in gram-negative bacterial growth and physiology: outside but fully integrated.Microbiology and molecular biology reviews : MMBR · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Journal of bacteriology · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. A mechanism for substrate quality control in outer membrane protein assembly.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article

130 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Jiawei SunDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Steven T RutherfordDepartment of Infectious Diseases, Genentech Inc., South San Francisco, CA, USA. rutherford.steven@gene.com.ORCID http://orcid.org/0000-0002-4758-4248
Thomas J SilhavyDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA. tsilhavy@princeton.edu.ORCID http://orcid.org/0000-0001-7672-5153
Kerwyn Casey HuangDepartment of Bioengineering, Stanford University, Stanford, CA, USA. kchuang@stanford.edu.ORCID http://orcid.org/0000-0002-8043-8138
Chan Zuckerberg Initiative (United States) · USGenVec · USPrinceton University · USStanford University · US

Funding

Biogenesis and maintenance of the outer membrane of Gram-negative bacteriaR35GM118024 · NIGMS · PRINCETON UNIVERSITY · PI SILHAVY, THOMAS J. · 2016 to 2025
$8.1M
A universal pipeline for functional characterization of the human microbiota at a massive scaleRM1GM135102 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BUIE, CULLEN RICHARD, DEUTSCHBAUER, ADAM M · 2020 to 2024
$7.6M
NIGMS NIH HHS R35 GM118024NIGMS NIH HHS RM1 GM135102
6 · The paper itself

Abstract

It has long been appreciated that the Gram-negative outer membrane acts as a permeability barrier, but recent studies have uncovered a more expansive and versatile role for the outer membrane in cellular physiology and viability. Owing to recent developments in microfluidics and microscopy, the structural, rheological and mechanical properties of the outer membrane are becoming apparent across multiple scales. In this Review, we discuss experimental and computational studies that have revealed key molecular factors and interactions that give rise to the spatial organization, limited diffusivity and stress-bearing capacity of the outer membrane. These physical properties suggest broad connections between cellular structure and physiology, and we explore future prospects for further elucidation of the implications of outer membrane construction for cellular fitness and survival.

Indexed as

Bacterial Outer MembraneBacterial Outer Membrane ProteinsCell MembraneGram-Negative BacteriaPermeabilityBacterial Outer Membrane Proteins

Identifiers

PMID34732874
PMCPMC8934262
OpenAlexW3208774826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.