ArticleScientific reports2021
Characterization of the SARS-CoV-2 genomes in Egypt in first and second waves of infection.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Analysis of the Spread and Evolution of COVID-19 Mutations in Ecuador Using Open Data.Life (Basel, Switzerland) · 2024Article
- VIPERA: Viral Intra-Patient Evolution Reporting and Analysis.Virus evolution · 2024Article
- Comparative genotyping of SARS-CoV-2 among Egyptian patients: near-full length genomic sequences versus selected spike and nucleocapsid regions.Medical microbiology and immunology · 2023Article
- "Day 25": a temporal indicator of stabilization of mortality risk among COVID-19 patients with high viral load.Tropical medicine and health · 2022Article
- Article
- The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance.Science (New York, N.Y.) · 2022Article
- Whole-genome sequencing of SARS-CoV-2 reveals diverse mutations in circulating Alpha and Delta variants during the first, second, and third waves of COVID-19 in South Kivu, east of the Democratic Republic of the Congo.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Article
- Determinants of the Development of SARS-CoV-2 Anti-Spike Immune-Response after Vaccination among Healthcare Workers in Egypt.Vaccines · 2022Article
- Understanding COVID-19-related myocarditis: pathophysiology, diagnosis, and treatment strategies.Cardiology plusReview
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
At Wuhan, in December 2019, the SRAS-CoV-2 outbreak was detected and it has been the pandemic worldwide. This study aims to investigate the mutations in sequence of the SARS-CoV-2 genome and characterize the mutation patterns in Egyptian COVID-19 patients during different waves of infection. The samples were collected from 250 COVID-19 patients and the whole genome sequencing was conducted using Next Generation Sequencing. The viral sequence analysis showed 1115 different genome from all Egyptian samples in the second wave mutations including 613 missense mutations, 431 synonymous mutations, 25 upstream gene mutations, 24 downstream gene mutations, 10 frame-shift deletions, and 6 stop gained mutation. The Egyptian genomic strains sequenced in second wave of infection are different to that of the first wave. We observe a shift of lineage prevalence from the strain B.1 to B.1.1.1. Only one case was of the new English B.1.1.7. Few samples have one or two mutations of interest from the Brazil and South Africa isolates. New clade 20B appear by March 2020 and 20D appear by May 2020 till January 2021.
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Registered trials
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