ArticlePediatric research2022
Growth pattern evaluation of the Edinburgh and Gothenburg cohorts by QEPS height model.
Article in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Growth patterns in patients with congenital adrenal hyperplasia analyzed by the QEPS growth model.Frontiers in endocrinology · 2026Article
- The Individual Relationship between Pubertal Growth and Physical Changes of Puberty in Healthy Adolescents.Hormone research in paediatrics · 2025Article
- Computerised Algorithms Showed Promise in Identifying Swedish Children With Atypical Growth Patterns.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Early life growth is related to pubertal growth and adult height - a QEPS-model analysis.Pediatric research · 2025Article
- A causal model of human growth and its estimation using temporally sparse data.Royal Society open science · 2025Article
- Timing of menarche and pubertal growth patterns using the QEPS growth model.Frontiers in pediatrics · 2024Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe QEPS-growth-model, developed and validated in GrowUp-Gothenburg cohorts, used for developing growth references and investigating healthy/pathological growth, lacks external validation from other longitudinal cohorts of healthy individuals.
aimTo investigate if the QEPS-model can fit the longitudinal Edinburgh growth study of another design than GrowUp-Gothenburg cohorts, and to compare growth patterns in the individuals born in mid-1970s in North-Western Europe.
methodsLongitudinal growth data were obtained from the Edinburgh and the GrowUp1974Gothenburg cohorts. The QEPS-model was used to describe length/height from birth to adult height with confidence interval, and the multivariable regression model for estimating the contribution of the different QEPS-functions to adult height.
resultsThe QEPS-model fitted the Edinburgh cohort well, with high accuracy, and low confidence intervals indicating high precision. Despite 3 cm shorter stature (less QE-function growth) in Scottish children, the growth patterns of the cohorts were similar, especially for specific pubertal growth. The contribution to adult height from different QEPS functions was similar.
conclusionThe QEPS-model is validated for the first time in a longitudinal study of healthy individuals of another design and found to fit with high accuracy and precision. The Scottish and Western-Swedish cohorts born in mid-1970s showed similar growth patterns for both sexes, especially pubertal growth. IMPACT: For the first time, the QEPS height model was used and found to fit another longitudinal cohort of healthy individuals other than the Swedish longitudinal cohorts. With large numbers of individual measurements in each growth phase, the QEPS model calculates growth estimates with narrow confidence intervals (high precision) and high accuracy. The two different cohorts born in the mid-1970s from Scotland and Western Sweden have similar growth patterns, despite a 3 cm difference in adult height.
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