ArticleScientific reports2021
Urine caffeine metabolites and hearing threshold shifts in US adults: a cross-sectional study.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- A Systematic Review on Metabolomics Analysis in Hearing Impairment: Is It a Possible Tool in Understanding Auditory Pathologies?International journal of molecular sciences · 2023Pooled it
- Association between coffee and caffeine consumption and chronic kidney disease.Scientific reports · 2025Article
- Association between caffeine intake from foods and beverages in the diet and hearing loss in United States adults.Frontiers in neurology · 2024Article
- Association of coffee consumption with the prevalence of hearing loss in US adults, NHANES 2003-2006.Public health nutrition · 2023Article
- Association of Coffee, Tea, and Caffeine Consumption With All-Cause Risk and Specific Mortality for Cardiovascular Disease Patients.Frontiers in nutrition · 2022Article
- Serum polyunsaturated fatty acids and hearing threshold shifts in adults in the United States: A cross-sectional study.Frontiers in public health · 2022Article
- Urinary pyrethroid metabolite and hearing threshold shifts of adults in the United States: A cross-sectional study.PloS one · 2022Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Previous studies have reported the relationship between effect of caffeine and many diseases. However, studies to evaluate the association between caffeine and hearing loss are contradictory. To examine the relationship of urinary caffeine metabolites with the hearing threshold in US adults, a total of 849 adults aged 20-69 years who participated in the National Health and Nutrition Examination Survey (NHANES, 2011-2012) were enrolled in this study. Urinary caffeine and its 14 metabolites were applied as biomarkers to assess caffeine exposure. Hearing loss was defined as mean pure tone averages > 25 dB HL at 500, 1000, and 2000 Hz in both ears (low frequency); and 3000, 4000, and 6000 Hz in both ears (high frequency). Univariate and multivariate linear regression analyses were conducted to examine the associations of urinary caffeine metabolites with low- and high-frequency hearing thresholds, respectively. Low-frequency hearing loss were 5.08% and 6.10% in male and female participants, respectively; and high-frequency hearing loss were 31.81% and 15.14% in male and female participants, respectively. In the unadjusted model, the P value for trend shows that urinary caffeine metabolites 137X and AAMU were significantly associated with low-frequency PTA, and that 17X, 137X, AAMU were significantly associated with high-frequency PTA, but when the model was adjusted for sex, age, education level, firearm noise exposure, occupational noise exposure, recreational noise exposure, serum cotinine, body mass index, diabetes, hypertension, these were no longer statistically significant. In conclusion, urinary caffeine metabolites were not associated with the hearing threshold shifts in US adults.
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