ReviewNature reviews. Disease primers2021
Restless legs syndrome.
Review in Nature reviews. Disease primers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
124 citing papers in PubMed, 8 syntheses or guidelines pooled it, 235 citations in OpenAlex.
- Repetitive transcranial magnetic stimulation for the treatment of restless legs syndrome: A meta-analysis.Medicine · 2026Pooled it
- Prevalence of restless legs syndrome in Pakistan: a systematic review and meta-analysis across diverse study populations.BMC neurology · 2026Pooled it
- Smoking and risk of restless leg syndrome: a systematic review, meta-analysis, and Mendelian randomisation.Journal of global health · 2026Pooled it
- Proposal for Managing Cancer-Related Insomnia: A Systematic Literature Review of Associated Factors and a Narrative Review of Treatment.Cancer medicine · 2024Pooled it
- The global and regional prevalence of restless legs syndrome among adults: A systematic review and modelling analysis.Journal of global health · 2024Pooled it
- Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction.Nature genetics · 2024Pooled it
- Restless legs syndrome and cognitive function among adults: a systematic review and meta-analysis.Journal of neurology · 2023Pooled it
- Polysomnographic nighttime features of Restless Legs Syndrome: A systematic review and meta-analysis.Frontiers in neurology · 2022Pooled it
- Effects of local vibration therapy and gabapentin on restless legs syndrome symptoms: a randomized controlled trial.BMC research notes · 2026Trial
- The effect of compression stockings on the complaints well-being and sleep quality of pregnant women with restless legs syndrome: a randomized controlled study.Revista da Associacao Medica Brasileira (1992) · 2024Trial
- Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.BMC complementary medicine and therapies · 2022Trial
- Italian adaptation of international recommendations for the management of restless legs syndrome: A consensus statement by the scientific committee of RLS-Italia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Emerging genetics of sleep and circadian disorders.Current opinion in pediatrics · 2026Article
- Parkinson's Disease: Pathophysiology, Treatment Strategies, Wellness Approaches, and Obstacles/Paths Forward.NeuroSci · 2026Review
- Expert consensus on osteoporosis risk management in patients with sleep disorders.Bone research · 2026Review
- Adherence to positive airway pressure therapy in patients with comorbid restless legs syndrome and obstructive sleep apnea: a retrospective cohort study.Sleep & breathing = Schlaf & Atmung · 2026Article
- Investigation of the "Not Better Explained" Diagnosis Criteria in Sleep Disorder Classifications: A Systematic Content Analysis and Critical Review.Journal of sleep research · 2026Review
- Disinhibition of cerebellar output by loss of restless legs syndrome-associated gene MEIS1.Current biology : CB · 2026Article
- Secondary Restless Legs Syndrome during psychopharmacological treatment: real-world evidence from a multinational pharmacovigilance program.The international journal of neuropsychopharmacology · 2026Article
- Associations between Primary Hyperhidrosis and Psychiatric Conditions: A Matched Case-Control Study of 8,508 Patients.Skin appendage disorders · 2026Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Restless legs syndrome (RLS) is a common sensorimotor disorder characterized by an urge to move that appears during rest or is exacerbated by rest, that occurs in the evening or night and that disappears during movement or is improved by movement. Symptoms vary considerably in age at onset, frequency and severity, with severe forms affecting sleep, quality of life and mood. Patients with RLS often display periodic leg movements during sleep or resting wakefulness. RLS is considered to be a complex condition in which predisposing genetic factors, environmental factors and comorbidities contribute to the expression of the disorder. RLS occurs alone or with comorbidities, for example, iron deficiency and kidney disease, but also with cardiovascular diseases, diabetes mellitus and neurological, rheumatological and respiratory disorders. The pathophysiology is still unclear, with the involvement of brain iron deficiency, dysfunction in the dopaminergic and nociceptive systems and altered adenosine and glutamatergic pathways as hypotheses being investigated. RLS is poorly recognized by physicians and it is accordingly often incorrectly diagnosed and managed. Treatment guidelines recommend initiation of therapy with low doses of dopamine agonists or α
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.