Evidence map›Paper›PMID 34732719›Full record

ArticleNature communications2021

Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia.

Janek S Walker, Zachary A Hing, Steven Sher, James Cronin, Katie Williams, Bonnie Harrington, Jordan N Skinner, Casey B Cempre, Charles T Gregory, Alexander Pan and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 2 institutions in 1 country.

Janek S Walker *Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-2049-1527
Zachary A Hing *Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Steven SherDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
James CroninDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Katie WilliamsDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Bonnie HarringtonDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Jordan N SkinnerDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Casey B CempreDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Charles T GregoryDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Alexander PanDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Max YanoDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Larry P BeaverDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Brandi R WalkerDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Jadwiga M LabanowskaDepartment of Pathology, The Ohio State University, Columbus, OH, USA.
Nyla A HeeremaDepartment of Pathology, The Ohio State University, Columbus, OH, USA.
Krzysztof MrózekThe Ohio State University Comprehensive Cancer Center, Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University, Columbus, OH, USA.
Jennifer A WoyachDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-3403-9144
Amy S RuppertDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-9612-6473
Amy LehmanCenter for Biostatistics, The Ohio State University, Columbus, OH, USA.
Hatice Gulcin OzerDepartment of Biomedical Informatics, The Ohio State University College of Medicine, Columbus, OH, USA.
Vincenzo CoppolaDepartment of Cancer Biology and Genetics, The Ohio State University College of Medicine, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-6163-1779
Pearlly YanDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0003-1965-4920
John C ByrdDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-9830-0711
James S BlachlyDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-4275-5562
Rosa LapalombellaDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA. rosa.lapalombella@osumc.edu.ORCID http://orcid.org/0000-0001-6916-9400
The Ohio State University · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Systems Analysis of Epigenomic Architecture in Cancer ProgressionU54CA217297 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HUANG, TIM H.-M. · 2017 to 2021
$9.3M
ONOCOLOGY TRAINING GRANTT32CA009338 · NCI · OHIO STATE UNIVERSITY · PI BYRD, JOHN C., POLLOCK, RAPHAEL E. · 1985 to 2018
$8.3M
Targeted Therapy for LeukemiaR35CA197734 · NCI · UNIVERSITY OF CINCINNATI · PI BYRD, JOHN C. · 2015 to 2021
$6.6M
Integrative Training in Biomedical SystemsT32GM068412 · NIGMS · OHIO STATE UNIVERSITY · PI PARVIN, JEFFREY D · 2005 to 2020
$2.4M
Targeted Therapies for Richters TransformationR01CA214046 · NCI · OHIO STATE UNIVERSITY · PI BAIOCCHI, ROBERT ALAN, BYRD, JOHN C. · 2017 to 2021
$2.3M
NRSA Training CoreTL1TR002735 · NCATS · OHIO STATE UNIVERSITY · PI BUMGARDNER, GINNY L, KIRSCHNER, LAWRENCE S · 2018 to 2022
$1.3M
Ultra-Low and Single-Cell Transcriptome Analysis in Patient-Derived Rare CLL Precursor CellsR50CA211524 · NCI · OHIO STATE UNIVERSITY · PI YAN, PEARLLY · 2016 to 2020
$745k
NCATS NIH HHS TL1 TR002735NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA214046NCI NIH HHS R35 CA197734NCI NIH HHS R50 CA211524NCI NIH HHS T32 CA009338NCI NIH HHS U54 CA217297NIGMS NIH HHS T32 GM068412
6 · The paper itself

Abstract

Rare, recurrent balanced translocations occur in a variety of cancers but are often not functionally interrogated. Balanced translocations with the immunoglobulin heavy chain locus (IGH; 14q32) in chronic lymphocytic leukemia (CLL) are infrequent but have led to the discovery of pathogenic genes including CCND1, BCL2, and BCL3. Following identification of a t(X;14)(q28;q32) translocation that placed the mature T cell proliferation 1 gene (MTCP1) adjacent to the immunoglobulin locus in a CLL patient, we hypothesized that this gene may have previously unrecognized importance. Indeed, here we report overexpression of human MTCP1 restricted to the B cell compartment in mice produces a clonal CD5

Indexed as

Translocation, GeneticAdultAgedAged, 80 and overAnimalsB-Cell Lymphoma 3 ProteinCyclin D1FemaleGene Expression RegulationGenes, Immunoglobulin Heavy ChainHumansImmunoglobulin Heavy ChainsLeukemia, Lymphocytic, Chronic, B-CellMaleMiceMice, Inbred C57BLB-Cell Lymphoma 3 ProteinBCL2 protein, humanBCL3 protein, humanCCND1 protein, humanCyclin D1Immunoglobulin Heavy ChainsMTCP1 protein, humanProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2

Identifiers

PMID34732719
PMCPMC8566464
OpenAlexW3210072499

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.