Evidence map›Paper›PMID 34732708›Full record

ArticleNature communications2021

Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis.

Alison E Jarmas, Eric W Brunskill, Praneet Chaturvedi, Nathan Salomonis, Raphael Kopan

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  5. A knock inbioRxiv : the preprint server for biology · 2026
    Article
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  16. Review
  17. Principles of human and mouse nephron development.Nature reviews. Nephrology · 2022
    Review
  18. Article
  19. Wnt-Fzd signals put the brakes on nephrogenesis.Nature reviews. Nephrology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alison E Jarmas *Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0000-0002-1797-2055
Eric W Brunskill *Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Praneet ChaturvediDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Nathan SalomonisDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0001-9689-2469
Raphael KopanDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Raphael.Kopan@cchmc.org.ORCID 0000-0002-0350-2730
Cincinnati Children's Hospital Medical Center · US

Funding

The Mechanism Regulating Renal Progenitor AgingR01DK106225 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI KOPAN, RAPHAEL · 2016 to 2020
$2.3M
SH800 Cell SorterS10OD023410 · OD · CINCINNATI CHILDRENS HOSP MED CTR · PI THORNTON, SHERRY L · 2017 to 2017
$318k
Identification of the genetic mechanisms governing mammalian nephron endowmentF30DK123841 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI JARMAS, ALISON · 2019 to 2022
$178k
NIDDK NIH HHS F30 DK123841NIDDK NIH HHS R01 DK106225NIH HHS S10 OD023410
6 · The paper itself

Abstract

Mammalian nephron endowment is determined by the coordinated cessation of nephrogenesis in independent niches. Here we report that translatome analysis in Tsc1

Indexed as

AnimalsCell DifferentiationFemaleFibroblast Growth FactorsHomeodomain ProteinsKidneyMaleMembrane ProteinsMiceNephronsNerve Tissue ProteinsOrganogenesisPerceptionStem Cell NicheStem CellsTranscription FactorsFgf20 protein, mouseFibroblast Growth FactorsHomeodomain ProteinsMembrane ProteinsNerve Tissue ProteinsSix2 protein, mouseTmem59 protein, mouseTranscription FactorsTsc1 protein, mouseTuberous Sclerosis Complex 1 Protein

Identifiers

PMID34732708
PMCPMC8566581
OpenAlexW3210281587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.