SynthesisWorld journal of surgical oncology2021
The efficacy of ileostomy after laparoscopic rectal cancer surgery: a meta-analysis.
Synthesis in World journal of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Understanding the link between ocular shape and myopia: a systematic review.BMJ open ophthalmology · 2026Pooled it
- Efficacy and safety of immunotherapy in anaplastic thyroid carcinoma: a systematic review and meta-analysis.International journal of surgery (London, England) · 2026Pooled it
- Preoperative risk factors and cumulative incidence of temporary ileostomy non-closure after sphincter-preserving surgery for rectal cancer: a meta-analysis.World journal of surgical oncology · 2024Pooled it
- Pooled it
- Effect of transanal drainage tube on prevention of anastomotic leakage after anterior rectal cancer surgery taking indwelling time into consideration: a systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- Comparison of purse-string technique vs linear suture for skin closure after ileostomy reversal. A randomized controlled trial.Langenbeck's archives of surgery · 2024Trial
- Predicting the risk of dehydration and readmission among rectal cancer patients with ileostomy: a multicenter observational study.Updates in surgery · 2026Article
- Effectiveness of a three-layer closure technique for preventing stoma-site incisional hernia after stoma closure in patients with rectal cancer.Surgery today · 2026Article
- Does the management of anastomotic leakage after rectal cancer resection affect long-term oncological survival? A retrospective propensity score-adjusted cohort study.Techniques in coloproctology · 2026Observational
- One-Stitch Versus Traditional Ileostomy After Low Anterior Resection for Rectal Cancer: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2026Article
- Gunsight closure versus conventional techniques for reversal of protective stoma after rectal cancer surgery: a propensity score matching study.International journal of colorectal disease · 2026Article
- Risk factors for bacterial translocation after loop ileostomy closure in patients with colorectal cancer.International journal of colorectal disease · 2025Article
- Comparison of purse-string technique versus linear suture for skin closure after stoma reversal: a meta-analysis of high-quality studies.Annals of coloproctology · 2025Review
- Machine learning-based prediction of permanent ileostomy in older adults after laparoscopic anterior resection for rectal cancer.Asia-Pacific journal of oncology nursing · 2025Article
- Vacuum-assisted self-expanding stents in colorectal surgery: early experiences with a novel tool.Surgical endoscopy · 2025Article
- Advanced innovations in reducing anastomotic leak: a review of emerging biomaterial applications in colorectal surgery.International journal of colorectal disease · 2025Review
- Robotic Versus Laparoscopic Versus Open Surgery for Rectal Cancer.Journal of clinical medicine · 2025Article
- Prevention of incisional hernia with biosynthetic mesh at the site of temporary ileostomy closure (PRINCESS Study): Preliminary Results.Hernia : the journal of hernias and abdominal wall surgery · 2025Observational
- Does robotic circumferential oversewing reduce anastomotic leakage in stapled anastomosis for rectal cancer surgery?Techniques in coloproctology · 2025Article
- Effect of one-stitch method of temporary ileostomy on the surgical outcomes and complications after laparoscopic low anterior resection in rectal cancer patients: a propensity score matching analysis.European journal of medical research · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundProtective ileostomy is always applied to avoid clinically significant anastomotic leakage and other postoperative complications for patients receiving laparoscopic rectal cancer surgery. However, whether it is necessary to perform the ileostomy is still controversial. This meta-analysis aims to analyze the efficacy of ileostomy on laparoscopic rectal cancer surgery.
methodsCochrane Library, EMBASE, Web of Science, and PubMed were applied for systematic search of all relevant literature, updated to May 07, 2021. Studies compared patients with and without ileostomy for laparoscopic rectal cancer surgery. We applied Review Manager software to perform this meta-analysis. The quality of the non-randomized controlled trials was assessed using the Newcastle-Ottawa scale (NOS), and the randomized studies were assessed using the Jadad scale.
resultsWe collected a total of 1203 references, and seven studies were included using the research methods. The clinically significant anastomotic leakage rate was significantly lower in ileostomy group (27/567, 4.76%) than that in non-ileostomy group (54/525, 10.29%) (RR = 0.47, 95% CI 0.30-0.73, P for overall effect = 0.0009, P for heterogeneity = 0.18, I
conclusionThe results demonstrated that protective ileostomy could decrease the clinically significant anastomotic leakage rate for patients undergoing laparoscopic rectal cancer surgery. However, ileostomy has no effect on postoperative hospital stay, reoperation, wound infection, and operation time. The efficacy of ileostomy after laparoscopic rectal cancer surgery: a meta-analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.