SynthesisJournal of neuroengineering and rehabilitation2021
Resting motor threshold in the course of hand motor recovery after stroke: a systematic review.
Synthesis in Journal of neuroengineering and rehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06108440 (Comparative Effects of Action Observation and Motor Imagery Training on Upper Limb Function in Chronic Stroke Patients), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Effects of Action Observation and Motor Imagery Training on Upper Limb Function in Chronic Stroke Patients
Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Trial
- The Effect of Action Observation Combined with Motor Imagery Training on Upper Extremity Function and Corticospinal Excitability in Stroke Patients: A Randomized Controlled Trial.International journal of environmental research and public health · 2022Trial
- The Test-Retest Reliability of Non-Navigated Transcranial Magnetic Stimulation (TMS) Measures of Corticospinal Pathway Excitability in a Neurologically Intact Adult Population.Brain topography · 2026Article
- Robust neurogenesis in chronic stroke monkeys following mesenchymal stem cell transplantation plus intermittent theta-burst stimulation.Signal transduction and targeted therapy · 2026Article
- Structural-functional connectivity coupling in motor-brain networks following acute ischemic stroke.Journal of neuroengineering and rehabilitation · 2026Article
- Comparison of the predictive value of upper limb somatosensory evoked potentials and motor evoked potentials for functional recovery in subacute stroke: a retrospective study.Journal of rehabilitation medicine · 2026Observational
- Association between corpus callosum microstructure and upper limb motor outcome in moderate-to-severe ischemic stroke patients at 3-6 months post-stroke.Frontiers in neurology · 2026Article
- EEG-timed neuromuscular stimulation shapes ipsilateral TMS-evoked motor responses in humans.Clinical neurophysiology practice · 2026Article
- Plasma sodium levels are related to resting motor threshold in healthy humans.Scientific reports · 2025Article
- Resting motor threshold in navigated transcranial magnetic stimulation: relationship between inter-individual variance and distinct clinical and anatomical factors.Acta neurochirurgica · 2025Article
- Corticomotor pathway function and recovery after stroke: a look back and a way forward.The Journal of physiology · 2025Review
- Intraoperative Cortical Sensorimotor Mapping During Glioma Resection Monitored With Drum Playing During Awake Craniotomy: A Case Report.Case reports in oncological medicine · 2025Article
- The impact of high-frequency rTMS treatment on brain activity in PSCI patients: a TMS-EEG study.Frontiers in neurology · 2025Article
- The efficacy of high-frequency repetitive transcranial magnetic stimulation on upper extremity function in intracerebral hemorrhage: a real-world retrospective cohort study.Frontiers in neurology · 2025Article
- Priming constraint-induced movement therapy with intermittent theta burst stimulation to enhance upper extremity recovery in patients with stroke: protocol for a randomized controlled study.Acta neurologica Belgica · 2024Article
- Differential impact of unilateral stroke on the bihemispheric motor cortex representation of the jaw and tongue muscles in young and aged rats.Frontiers in neurology · 2024Article
- Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Review
- The assessment of interhemispheric imbalance using functional near-infrared spectroscopic and transcranial magnetic stimulation for predicting motor outcome after stroke.Frontiers in neuroscience · 2023Article
- Clinical Effectiveness of Non-Immersive Virtual Reality Tasks for Post-Stroke Neuro-Rehabilitation of Distal Upper-Extremities: A Case Report.Journal of clinical medicine · 2022Article
- Application of Multi-Dimensional Intelligent Visual Quantitative Assessment System to Evaluate Hand Function Rehabilitation in Stroke Patients.Brain sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundResting motor threshold is an objective measure of cortical excitability. Numerous studies indicate that the success of motor recovery after stroke is significantly determined by the direction and extent of cortical excitability changes. A better understanding of this topic (particularly with regard to the level of motor impairment and the contribution of either cortical hemisphere) may contribute to the development of effective therapeutical strategies in this cohort.
objectivesThis systematic review collects and analyses the available evidence on resting motor threshold and hand motor recovery in stroke patients.
methodsPubMed was searched from its inception through to 31/10/2020 on studies investigating resting motor threshold of the affected and/or the non-affected hemisphere and motor function of the affected hand in stroke cohorts.
resultsOverall, 92 appropriate studies (including 1978 stroke patients and 377 healthy controls) were identified. The analysis of the data indicates that severe hand impairment is associated with suppressed cortical excitability within both hemispheres and with great between-hemispheric imbalance of cortical excitability. Favorable motor recovery is associated with an increase of ipsilesional motor cortex excitability and reduction of between-hemispheric imbalance. The direction of change of contralesional motor cortex excitability depends on the amount of hand motor impairment. Severely disabled patients show an increase of contralesional motor cortex excitability during motor recovery. In contrast, recovery of moderate to mild hand motor impairment is associated with a decrease of contralesional motor cortex excitability.
conclusionsThis data encourages a differential use of rehabilitation strategies to modulate cortical excitability. Facilitation of the ipsilesional hemisphere may support recovery in general, whereas facilitation and inhibition of the contralesional hemisphere may enhance recovery in severe and less severely impaired patients, respectively.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.