Evidence map›Paper›PMID 34732130›Full record

ArticleBMC genomics2021

Role of DNA methylation on the association between physical activity and cardiovascular diseases: results from the longitudinal multi-ethnic study of atherosclerosis (MESA) cohort.

Hangchuan Shi, Deborah J Ossip, Nicole L Mayo, Daniel A Lopez, Robert C Block, Wendy S Post, Alain G Bertoni, Jingzhong Ding, Si Chen, Chen Yan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Molecular Effects of Physical Activity and Body Composition: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2025
    Pooled it
  2. Article
  3. Review
  4. Review
  5. A Multiscale Spatiotemporal Epidemiological Analysis of Neighborhood Correlates of Triple-Negative Breast Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hangchuan ShiDepartment of Clinical and Translational Research, University of Rochester Medical Center, Rochester, NY, 14642-0708, USA.
Deborah J OssipDepartment of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Nicole L MayoDepartment of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Daniel A LopezDepartment of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Robert C BlockDepartment of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Wendy S PostDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Alain G BertoniDivision of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Jingzhong DingDepartment of Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, 27157, USA.
Si ChenAab Cardiovascular Research Institute, University of Rochester, School of Medicine and Dentistry, Rochester, NY, 14642, USA.
Chen YanAab Cardiovascular Research Institute, University of Rochester, School of Medicine and Dentistry, Rochester, NY, 14642, USA.
Zidian XieDepartment of Clinical and Translational Research, University of Rochester Medical Center, Rochester, NY, 14642-0708, USA.
Ina HoescheleDepartment of Statistics, Fralin Life Sciences Institute at Virginia Tech, Blacksburg, VA, 24061, USA.
Yongmei LiuDepartment of Medicine, Division of Cardiology, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, 27701, USA. yongmei.liu@duke.edu.
Dongmei LiDepartment of Clinical and Translational Research, University of Rochester Medical Center, Rochester, NY, 14642-0708, USA. Dongmei_Li@urmc.rochester.edu.

Funding

The University of Rochester's Clinical and Translational Science InstituteUL1TR002001 · NCATS · UNIVERSITY OF ROCHESTER · PI WILSON, KAREN M., ZAND, MARTIN S · 2016 to 2024
$34.6M
NCATS NIH HHS UL1 TR002001
6 · The paper itself

Abstract

backgroundThe complexity of physical activity (PA) and DNA methylation interaction in the development of cardiovascular disease (CVD) is rarely simultaneously investigated in one study. We examined the role of DNA methylation on the association between PA and CVD.

resultsThe Multi-Ethnic Study of Atherosclerosis (MESA) cohort Exam 5 data with 1065 participants free of CVD were used for final analysis. The quartile categorical total PA variable was created by activity intensity (METs/week). During a median follow-up of 4.0 years, 69 participants developed CVD. Illumina HumanMethylation450 BeadChip was used to provide genome-wide DNA methylation profiles in purified human monocytes (CD14+). We identified 23 candidate DNA methylation loci to be associated with both PA and CVD. We used the structural equation modeling (SEM) approach to test the complex relationships among multiple variables and the roles of mediators. Three of the 23 identified loci (corresponding to genes VPS13D, PIK3CD and VPS45) remained as significant mediators in the final SEM model along with other covariates. Bridged by the three genes, the 2nd PA quartile (β = - 0.959; 95%CI: - 1.554 to - 0.449) and the 3rd PA quartile (β = - 0.944; 95%CI: - 1.628 to - 0.413) showed the greatest inverse associations with CVD development, while the 4th PA quartile had a relatively weaker inverse association (β = - 0.355; 95%CI: - 0.713 to - 0.124).

conclusionsThe current study is among the first to simultaneously examine the relationships among PA, DNA methylation, and CVD in a large cohort with long-term exposure. We identified three DNA methylation loci bridged the association between PA and CVD. The function of the identified genes warrants further investigation in the pathogenesis of CVD.

Indexed as

AtherosclerosisCardiovascular DiseasesDNA MethylationEthnicityExerciseHumansRisk FactorsCardiovascular diseaseDNA methylationMESAPhysical activityStructural equation modeling

Identifiers

PMID34732130
PMCPMC8567593

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.