Evidence map›Paper›PMID 34732058›Full record

ArticleAmerican journal of Alzheimer's disease and other dementias

Identification of Hub Genes Related to Alzheimer's Disease and Major Depressive Disorder.

Yajing Cheng, Meiyue Sun, Feng Wang, Xin Geng, Fei Wang

Open access · goldAbstract read
In one paragraph

Article in American journal of Alzheimer's disease and other dementias. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Single-cell landscape of sex-specific drivers of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yajing ChengDepartment of Neurology, General Hospital, 117865Tianjin Medical University, Tianjin, China.ORCID 0000-0002-9851-1559
Meiyue SunDepartment of Neurology, General Hospital, 117865Tianjin Medical University, Tianjin, China.
Feng WangDepartment of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Xin GengDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, 117865Tianjin Medical University, Tianjin, China.
Fei WangDepartment of Neurology, General Hospital, 117865Tianjin Medical University, Tianjin, China.
Tianjin Medical University General Hospital · CNTianjin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundAlthough many studies reported a close relationship between depression and Alzheimer's disease (AD), the underlying pathophysiological mechanism remains unclear. The present study aimed to investigate the mechanism of AD and major depressive disorder (MDD).

Indexed as

Alzheimer DiseaseMajor Depressive DisorderMicroRNAsComputational BiologyGene Expression ProfilingGene OntologyGene Regulatory NetworksHumansProtein Interaction MapsMicroRNAsAlzheimer’s diseasedifferentially expressed geneshub genemajor depressive disorderpathophysiology association

Identifiers

PMID34732058
PMCPMC10695082
OpenAlexW3209411397

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.