Evidence map›Paper›PMID 34732056›Full record

ArticleThe American surgeon2022

Diagnostic Laparoscopy in Patients With Peritoneal Carcinomatosis Is Safe and Does Not Delay Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy.

David N Hanna, Muhammad O Ghani, Andrew Hermina, Alexander Mina, Christina E Bailey, Kamran Idrees, Deepa Magge

Open access · greenAbstract read
In one paragraph

Article in The American surgeon, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

David N HannaSection of Surgical Sciences, Division of Surgical Oncology and Endocrine Surgery, 12328Vanderbilt University Medical Center, Nashville, TN, USA.ORCID https://orcid.org/0000-0003-2530-0328
Muhammad O GhaniSection of Surgical Sciences, Division of Surgical Oncology and Endocrine Surgery, 12328Vanderbilt University Medical Center, Nashville, TN, USA.
Andrew Hermina5708Meharry Medical College, Nashville, TN, USA.
Alexander Mina12327Vanderbilt University School of Medicine, Nashville, TN, USA.
Christina E BaileySection of Surgical Sciences, Division of Surgical Oncology and Endocrine Surgery, 12328Vanderbilt University Medical Center, Nashville, TN, USA.
Kamran IdreesSection of Surgical Sciences, Division of Surgical Oncology and Endocrine Surgery, 12328Vanderbilt University Medical Center, Nashville, TN, USA.
Deepa MaggeSection of Surgical Sciences, Division of Surgical Oncology and Endocrine Surgery, 12328Vanderbilt University Medical Center, Nashville, TN, USA.
Vanderbilt University Medical Center · USMeharry Medical College · USVanderbilt University · US

Funding

Surgical Oncology Training GrantT32CA106183 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI James Richard Goldenring · 2004 to 2026
$6.0M
NCI NIH HHS T32 CA106183
6 · The paper itself

Abstract

backgroundOutcomes of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) among patients with peritoneal carcinomatosis (PC) depend largely on the extent of peritoneal disease. Since PC is not reliably evaluated with cross-sectional imaging, tumor burden is often evaluated with diagnostic laparoscopy (DLS). The aims of this study are to evaluate the safety of DLS in patients with peritoneal disease and determine if DLS delays time to CRS-HIPEC.

methodsWe performed an institutional retrospective review of 145 patients who underwent CRS-HIPEC between 2013 and 2020. Patients were divided into 2 groups: those who underwent an electively scheduled DLS prior to CRS-HIPEC and those who did not. Intraoperative and postoperative complications associated with DLS were determined from the surgeon's operative report. Time from diagnosis of PC to CRS-HIPEC was compared between the 2 groups.

resultsOf the 145 patients available for analysis, 47% (68) underwent DLS and 44% (64) did not. Of all the diagnostic laparoscopies performed, there was 1 (1.5%) intraoperative complication. The duration between diagnosis of peritoneal carcinomatosis and surgery was 4.9 months among patients who underwent DLS prior to CRS-HIPEC and 4.3 months among patients who did not (

conclusionIn this retrospective analysis, diagnostic laparoscopy prior to CRS-HIPEC demonstrated a comparable rate of DLS-associated complications compared to other gastrointestinal malignancies and does not prolong time from diagnosis to CRS-HIPEC. Thus, in patients undergoing evaluation for CRS-HIPEC, diagnostic laparoscopy provides significant value in patient selection without incurring perioperative risk or delay in CRS-HIPEC.

Indexed as

Colorectal NeoplasmsHyperthermia, InducedLaparoscopyPeritoneal NeoplasmsAntineoplastic Combined Chemotherapy ProtocolsChemotherapy, Cancer, Regional PerfusionCombined Modality TherapyCytoreduction Surgical ProceduresHumansHyperthermic Intraperitoneal ChemotherapyRetrospective Studiescytoreductive surgery with hyperthermic intraperitoneal chemotherapydiagnostic laparoscopyhyperthermic intraperitoneal chemotherapyperitoneal carcinomatosissurgical oncology

Identifiers

PMID34732056
PMCPMC9069552
OpenAlexW3208476698

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.