ArticleCirculation. Genomic and precision medicine2021
Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations With Atrial Fibrillation.
Open access · greenAbstract read
In one paragraph
Article in Circulation. Genomic and precision medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Genomic data-driven framework for drug target discovery in atrial fibrillation.Journal of translational medicine · 2025Pooled it
- Variant-to-function dissection of the 17q21.31 locus resolves ANKRD1 as a convergent regulatory target.BMC medical genomics · 2026Article
- Genetic drivers of progression in Alzheimer's disease are distinct from disease risk.Alzheimer's research & therapy · 2026Article
- Genomic structural equation modeling reveals shared genetic structure of cardiac function and structure-function association studies of CLCNKA mutations.Scientific reports · 2026Article
- Genetic drivers of progression in Alzheimer's disease are distinct from disease risk.medRxiv : the preprint server for health sciences · 2025Article
- Mechanistic Pathways Underlying Genetic Predisposition to Atrial Fibrillation Are Associated With Different Cardiac Phenotypes and Cardioembolic Stroke Risk.Circulation. Genomic and precision medicine · 2025Article
- Striving Towards Equity in Cardiovascular Genomics Research.Current atherosclerosis reports · 2025Review
- Metabonomic Biomarkers of Plaque Burden and Instability in Patients With Coronary Atherosclerotic Disease After Moderate Lipid-Lowering Therapy.Journal of the American Heart Association · 2024Article
- Exploring the possible causal effects of cardiac blood biomarkers in dementia and cognitive performance: a Mendelian randomization study.GeroScience · 2023Article
- Genome-wide detection of m6A-associated SNPs in atrial fibrillation pathogenesis.Frontiers in cardiovascular medicine · 2023Article
- Microvascular and macrovascular complications of type 2 diabetes mellitus: Exome wide association analyses.Frontiers in endocrinology · 2023Article
- Genetics of BAG3: A Paradigm for Developing Precision Therapies for Dilated Cardiomyopathies.Journal of the American Heart Association · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 11 institutions in 4 countries.
Yunju YangThe Center for Human Genetics, The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, Houston, TX (Y.Y., M.F.).ORCID 0000-0002-9747-8363
Traci M BartzCardiovascular Health Research Unit, Department of Medicine (T.M.B., J.A.B., B.M.P.), University of Washington, Seattle, WA.
Michael R BrownDepartment of Epidemiology, Human Genetics & Environmental Sciences and Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX (M.R.B., E.B., M.F., G.J., B.Y.).ORCID 0000-0002-5235-9037
Xiuqing GuoDepartment of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (X.G., J.Y., H.J.L., J.I.R.).ORCID 0000-0002-5264-5068
Nuno R ZilhãoIcelandic Heart Association, Kopavogur, Iceland (N.R.Z., V.G.).
Stella TrompetDepartment of Cardiology (S.T., J.W.J.), Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0001-5006-0528
Stefan WeissDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and University of Greifswald, Greifswald, Germany (S.W.).ORCID 0000-0002-3553-4315
Jie YaoDepartment of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (X.G., J.Y., H.J.L., J.I.R.).ORCID 0000-0002-8822-0651
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine (T.M.B., J.A.B., B.M.P.), University of Washington, Seattle, WA.ORCID 0000-0001-8509-148X
Christopher R DefilippiInova Heart and Vascular Institute, Falls Church, VA (C.R.D.).ORCID 0000-0002-0660-4943
Ron C HoogeveenDivision of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX (R.C.H., C.M.B.).ORCID 0000-0003-2399-4653
Henry J LinDepartment of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (X.G., J.Y., H.J.L., J.I.R.).ORCID 0000-0001-6771-0486
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland (N.R.Z., V.G.).ORCID 0000-0001-5696-0084
Christie M BallantyneDivision of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX (R.C.H., C.M.B.).ORCID 0000-0002-6432-1730
Marcus DörrGerman Centre for Cardiovascular Research, Partner Site Greifswald, Greifswald, Germany (S.W., M.D.).ORCID 0000-0001-7471-475X
J Wouter JukemaDepartment of Cardiology (S.T., J.W.J.), Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-3246-8359
Astrid PetersmannInstitute of Clinical Chemistry and Laboratory Medicine (A.P.), University Medicine Greifswald, Greifswald, Germany.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine (T.M.B., J.A.B., B.M.P.), University of Washington, Seattle, WA.ORCID 0000-0002-7278-2190
Jerome I RotterDepartment of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (X.G., J.Y., H.J.L., J.I.R.).ORCID 0000-0001-7191-1723
Eric BoerwinkleDepartment of Epidemiology, Human Genetics & Environmental Sciences and Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX (M.R.B., E.B., M.F., G.J., B.Y.).
Myriam FornageThe Center for Human Genetics, The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, Houston, TX (Y.Y., M.F.).ORCID 0000-0003-0677-8158
Goo JunDepartment of Epidemiology, Human Genetics & Environmental Sciences and Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX (M.R.B., E.B., M.F., G.J., B.Y.).ORCID 0000-0003-0891-0204
Bing YuDepartment of Epidemiology, Human Genetics & Environmental Sciences and Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX (M.R.B., E.B., M.F., G.J., B.Y.).ORCID 0000-0003-4818-1077
The University of Texas Health Science Center at Houston · USUCLA Medical Center · USUniversitätsmedizin Greifswald · DEUniversity of Washington · USBrown Foundation · USLeiden University Medical Center · NLAlaska Heart and Vascular Institute · USBaylor College of Medicine · USHouston Methodist · USIcelandic Heart Association · ISUniversity of Iceland · IS
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MTranslational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MTask Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2MEpidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8MExceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MNCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL141824NHLBI NIH HHS R01 HL148218NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS N01 AG012100NIA NIH HHS R01 AG023629NICHD NIH HHS R03 HD098552NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK118631
Abstract
backgroundElevated cardiac troponin levels in blood are associated with increased risk of cardiovascular diseases and mortality. Cardiac troponin levels are heritable, but their genetic architecture remains elusive.
methodsWe conducted a transethnic genome-wide association analysis on high-sensitivity cTnT (cardiac troponin T; hs-cTnT) and high-sensitivity cTnI (cardiac troponin I; hs-cTnI) levels in 24 617 and 14 336 participants free of coronary heart disease and heart failure from 6 population-based cohorts, followed by a series of bioinformatic analyses to decipher the genetic architecture of hs-cTnT and hs-cTnI.
resultsWe identified 4 genome-wide significant loci for hs-cTnT including a novel locus rs3737882 in
conclusionsWe identified a novel genetic locus associated with hs-cTnT in a multiethnic population and found that genetically regulated troponin levels were associated with atrial fibrillation.
Indexed as
Atrial FibrillationTroponin TAdaptor Proteins, Signal TransducingAnoctaminsApoptosis Regulatory ProteinsBiomarkersGenome-Wide Association StudyHumansTroponin IAdaptor Proteins, Signal TransducingANO5 protein, humanAnoctaminsApoptosis Regulatory ProteinsBAG3 protein, humanBiomarkersTroponin ITroponin Tcardiovascular diseasesgenome-wide association studyheart failureMendelian randomization analysistroponin Itroponin T
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.