ArticleEpilepsy & behavior : E&B2021
COVID-19 prevalence and mortality in people with epilepsy: A nation-wide multicenter study.
Article in Epilepsy & behavior : E&B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- A prospective observational study evaluating drug-related problems and their impact on patient-related outcomes in hospitalized epileptic patients.Scientific reports · 2026Observational
- European Reference Networks - a flagship activity of the EU in the field of rare and complex diseases: from 2017 to 2025.Orphanet journal of rare diseases · 2026Review
- Exploring the long-term effects of COVID-19 in patients with epilepsy: A multicenter Italian observational study.Epilepsia open · 2025Observational
- Mortality of Epilepsy in Chinese Populations: A Comprehensive Review.Neuroepidemiology · 2025Review
- Clinical outcomes of patients with seizure admitted for COVID-19: Findings from the Philippine CORONA study.Heliyon · 2024Article
- Mortality and mortality disparities among people with epilepsy in the United States, 2011-2021.Epilepsy & behavior : E&B · 2024Article
- Virus-Induced Epilepsy vs. Epilepsy Patients Acquiring Viral Infection: Unravelling the Complex Relationship for Precision Treatment.International journal of molecular sciences · 2024Review
- Factors Associated with Adverse Outcomes among SARS-CoV-2 Positive Children in a Tertiary Government COVID-19 Referral Hospital in the Philippines.Acta medica Philippina · 2024Article
- An update of the reported effects of the COVID-19 pandemic on person with intellectual disability and their carers: a scoping review.Annals of medicine · 2023Article
- Seizures in COVID-19: the relationship between biomarkers and prognosis.Acta neurologica Belgica · 2023Article
- Interaction between COVID-19 and epilepsy during the omicron surge: A cross-sectional survey conducted in China tertiary hospital.Epilepsy & behavior reports · 2023Article
- Changes in sleep quality of children with epilepsy and anxiety of their caregivers after COVID-19 infection: a case-series report.Frontiers in pediatrics · 2023Article
- Impact of COVID-19 pandemic on physical and mental health status and care of adults with epilepsy in Germany.Neurological research and practice · 2022Article
- Observational retrospective analysis of vaccination against SARS-CoV-2 and seizures: VACCI-COVID registry.Epilepsy & behavior : E&B · 2022Observational
- Seizure control during the COVID-19 pandemic: Correlating Responsive Neurostimulation System data with patient reports.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Article
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Authors and funding
24 authors at 14 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo assess the prevalence, severity, and mortality of COVID-19 in people with epilepsy (PWE) and evaluate seizure control in PWE during and after COVID-19.
methodsRetrospective, observational, multicenter study conducted in 14 hospitals. Medical records of randomly selected PWE followed at neurology outpatient clinics were reviewed. Proportion of PWE with a positive test for SARS-CoV-2 during 2020 was calculated. Risk factors associated with COVID-19 and its morbimortality were evaluated.
results2751 PWE were included, mean age 48.8 years (18-99), 72.4% had focal epilepsy, and 35% were drug-refractory. COVID-19 prevalence in PWE was 5.53%, while in the Spanish population was 4.26%. Proportion of admissions to hospital, ICU, and deaths in PWE were 17.1%, 2%, and 4.61% of COVID-19 cases, while in Spanish population were 10.81%, 0.95%, and 2.57%, respectively. A severe form of COVID-19 occurred in 11.8%; dyslipidemia, institutionalization at long-term care facilities, intellectual disability, and older age were associated risk factors. Older age, hypertension, dyslipidemia, cardiac disease, and institutionalization were associated with mortality from COVID-19. Seizure control was stable in 90.1% of PWE during acute COVID-19, while 8.6% reported an increase in seizure frequency. During post-COVID-19 follow-up, 4.6% reported seizure control worsening.
conclusionsCOVID-19 was moderately prevalent in PWE. One out of 5 patients required medical attention and 4.6% died due to COVID-19. Older age, dyslipidemia, institutionalization, and intellectual disability were significant risk factors associated with severe COVID-19. Seizure control remained stable during COVID-19 and throughout long-term follow-up in most PWE who contracted the infection.
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