Evidence map›Paper›PMID 34731674›Full record

ArticleCurrent biology : CB2021

xbx-4, a homolog of the Joubert syndrome gene FAM149B1, acts via the CCRK and RCK kinase cascade to regulate cilia morphology.

Ashish K Maurya, Piali Sengupta

Open access · greenAbstract read
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Joubert syndrome genemicroPublication biology · 2026
    Article
  3. Article
  4. Article
  5. Novel compound heterozygous variants in theFrontiers in pediatrics · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ashish K MauryaDepartment of Biology, MS008, Brandeis University, 415 South Street, Waltham, MA 02454, USA. Electronic address: ashishkm@brandeis.edu.
Piali SenguptaDepartment of Biology, MS008, Brandeis University, 415 South Street, Waltham, MA 02454, USA. Electronic address: sengupta@brandeis.edu.
Brandeis University · US

Funding

Mechanisms of sensory neuron morphological diversification, signaling, and functional plasticityR35GM122463 · NIGMS · BRANDEIS UNIVERSITY · PI Piali Sengupta · 2017 to 2026
$7.7M
NIGMS NIH HHS R35 GM122463
6 · The paper itself

Abstract

Primary cilia are microtubule (MT)-based organelles that mediate sensory functions in multiple cell types. Disruption of cilia structure or function leads to a diverse collection of diseases termed ciliopathies.

Indexed as

Caenorhabditis elegans ProteinsCiliaAbnormalities, MultipleAnimalsCaenorhabditis elegansCerebellumEye AbnormalitiesHumansKidney Diseases, CysticMitogen-Activated Protein KinasesProtein Serine-Threonine KinasesRetinaCaenorhabditis elegans ProteinsDYF-18 protein, C elegansDYF-5 protein, C elegansMitogen-Activated Protein KinasesProtein Serine-Threonine KinasesCCRK/RCKC. elegansciliaDUF3719FAM149B1Joubert syndromexbx-4

Identifiers

PMID34731674
PMCPMC8692433
OpenAlexW3208796272

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.