ArticleCell reports2021
Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition.
Open access · goldAbstract read
In one paragraph
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 34 citations in OpenAlex.
- Regional organization of nutrient absorption across the small intestine.Nature reviews. Gastroenterology & hepatology · 2026Review
- Intestinal Epithelial MHC-II at the Interface of Microbiota, Immunity, and Inflammation.International journal of molecular sciences · 2026Review
- The intestinal microbiota as a key modulator of acute graft-versus-host disease.Nature reviews. Cancer · 2026Review
- Weaning drives microbiome-mediated epigenetic regulation to shape immune memory in mice.Nature microbiology · 2026Article
- Oesophageal Epithelial Cell-Intrinsic MHCII Regulates Food Antigen-Dependent Eosinophilic Esophagitis in an IFNγ-Dependent Manner.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Article
- MicroRNA-146a Protects against Hepatocellular Carcinoma through Suppression of CCL5.Cancer research communications · 2026Article
- Pre-surgery gut microbial diversity and abundance are associated with post-surgery onset of cachexia in colorectal cancer patients: the ColoCare Study.Cancer causes & control : CCC · 2025Article
- From Cytokines to Biomarkers: Mapping the Immunopathology of Inflammatory Bowel Disease.Cells · 2025Review
- A capsular polysaccharide from a healthy human microbiota member activates a Lag-3-NK cell axis to restrain colon cancer and augment immunotherapy.Cell reports · 2025Article
- More than a leaky gut: how gut priming shapes arthritis.Nature reviews. Rheumatology · 2025Review
- AF6 regulates intestinal IgA via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel disease.iScience · 2025Article
- The gut microbiome is associated with disease-free survival in stage I-III colorectal cancer patients.International journal of cancer · 2025Article
- Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development.Science (New York, N.Y.) · 2025Article
- Clec12a controls colitis by tempering inflammation and restricting expansion of specific commensals.Cell host & microbe · 2025Article
- MHC class II of different non-professional antigen-presenting cells mediate multiple effects of crosstalk with CD4Frontiers in medicine · 2025Review
- Multi-omics analysis reveals the genetic and environmental factors in shaping the gut resistome of a keystone rodent species.Science China. Life sciences · 2024Article
- RETRACTED: Effect ofMicroorganisms · 2024Article
- Intestinal Transplant Immunology and Intestinal Graft Rejection: From Basic Mechanisms to Potential Biomarkers.International journal of molecular sciences · 2023Review
- Small Intestinal Microbiota Oscillations, Host Effects and Regulation-A Zoom into Three Key Effector Molecules.Biology · 2023Review
- Context-Dependent Regulation of Type17 Immunity by Microbiota at the Intestinal Barrier.Immune network · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 2 countries.
W Zac StephensUniversity of Utah School of Medicine, Department of Pathology, Division of Microbiology and Immunology, Salt Lake City, UT 84112, USA.
Jason L KubinakUniversity of South Carolina School of Medicine, Department of Pathology, Microbiology and Immunology, Columbia, SC 29209, USA.
Arevik GhazaryanUniversity of Utah School of Medicine, Department of Pathology, Division of Microbiology and Immunology, Salt Lake City, UT 84112, USA.
Kaylyn M BauerUniversity of Utah School of Medicine, Department of Pathology, Division of Microbiology and Immunology, Salt Lake City, UT 84112, USA.
Rickesha BellUniversity of Utah School of Medicine, Department of Pathology, Division of Microbiology and Immunology, Salt Lake City, UT 84112, USA.
Kate BuhrkeUniversity of Utah School of Medicine, Department of Pathology, Division of Microbiology and Immunology, Salt Lake City, UT 84112, USA.
Tyson R ChiaroUniversity of Utah School of Medicine, Department of Pathology, Division of Microbiology and Immunology, Salt Lake City, UT 84112, USA.
Allison M WeisUniversity of Utah School of Medicine, Department of Pathology, Division of Microbiology and Immunology, Salt Lake City, UT 84112, USA.
William W TangUniversity of Utah School of Medicine, Department of Pathology, Division of Microbiology and Immunology, Salt Lake City, UT 84112, USA.
Josh K MontsUniversity of Utah School of Medicine, Flow Cytometry Core, Health Sciences Center, Salt Lake City, UT 84112, USA.
Ray SotoUniversity of Utah School of Medicine, Department of Pathology, Division of Microbiology and Immunology, Salt Lake City, UT 84112, USA.
H Atakan EkizUniversity of Utah School of Medicine, Department of Pathology, Division of Microbiology and Immunology, Salt Lake City, UT 84112, USA; Izmir Institute of Technology, Molecular Biology and Genetics Department, Gulbahce, Izmir 35430, Turkey.
Ryan M O'ConnellUniversity of Utah School of Medicine, Department of Pathology, Division of Microbiology and Immunology, Salt Lake City, UT 84112, USA. Electronic address: ryan.oconnell@path.utah.edu.
June L RoundUniversity of Utah School of Medicine, Department of Pathology, Division of Microbiology and Immunology, Salt Lake City, UT 84112, USA. Electronic address: june.round@path.utah.edu.
University of Utah · USIzmir Institute of Technology · TRUniversity of South Carolina · US
Funding
UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6MMicrobiota-immune interactions that promote intestinal homeostasisR01AT011423 · NCCIH · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ROUND, JUNE LOUISE · 2021 to 2025
$3.1MBacteriophage pathobiology of inflammatory bowel diseaseR01DK124317 · NIDDK · UNIVERSITY OF UTAH · PI ROUND, JUNE LOUISE · 2020 to 2023
$2.5MDeveloping therapies to target the microbiotaDP2AT008746 · NCCIH · UNIVERSITY OF UTAH · PI ROUND, JUNE LOUISE · 2014 to 2014
$2.2MB-cell-intrinsic MHCII Signaling is a Diversifying Force of Selection on IgA Repertoires and the Gut MicrobiotaR01AI155887 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KUBINAK, JASON L · 2021 to 2025
$2.1MInvestigating the transfer of miRNAs by exosomes during inflammationR01AI123106 · NIAID · UNIVERSITY OF UTAH · PI O'CONNELL, RYAN M · 2017 to 2021
$2.0MMechanisms of fungal involvement during intestinal diseaseR01DK124336 · NIDDK · UNIVERSITY OF UTAH · PI ROUND, JUNE LOUISE · 2020 to 2023
$1.8MCross-disciplinary Training in Immunology, Inflammation and Infectious DiseaseT32AI138945 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Tracey Jane Lamb, Matthew A Williams · 2018 to 2026
$1.6MAmnis ImageStreamX MarkII Imaging Flow CytometerS10OD026959 · OD · UNIVERSITY OF UTAH · PI MARVIN, JAMES E · 2020 to 2020
$517kUniv of Utah Cell Sorter for Flow Cytometry CoreS10RR026802 · NCRR · UNIVERSITY OF UTAH · PI GREEN, WAYNE FRANCIS · 2010 to 2010
$500kMechanism of MHC heterozygote advantage during anti-commensal germinal center B cell selectionR21AI142409 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KUBINAK, JASON L · 2019 to 2020
$410kExploring how B cell Maturation Pathways Influence Microbiota Composition and Host HealthK22AI123481 · NIAID · UNIVERSITY OF TEXAS ARLINGTON · PI KUBINAK, JASON L · 2017 to 2018
$263kNCCIH NIH HHS DP2 AT008746NCCIH NIH HHS R01 AT011423NCI NIH HHS F30 CA260977NCI NIH HHS P30 CA042014NCRR NIH HHS S10 RR026802NIAID NIH HHS K22 AI123481NIAID NIH HHS R01 AI123106NIAID NIH HHS R01 AI155887NIAID NIH HHS R21 AI142409NIAID NIH HHS T32 AI138945NIDDK NIH HHS R01 DK124317NIDDK NIH HHS R01 DK124336NIH HHS S10 OD026959
Abstract
Intestinal epithelial cells (IECs) have long been understood to express high levels of major histocompatibility complex class II (MHC class II) molecules but are not considered canonical antigen-presenting cells, and the impact of IEC-MHC class II signaling on gut homeostasis remains enigmatic. As IECs serve as the primary barrier between underlying host immune cells, we reasoned that IEC-intrinsic antigen presentation may play a role in responses toward the microbiota. Mice with an IEC-intrinsic deletion of MHC class II (IEC
Indexed as
Adaptive ImmunityGastrointestinal MicrobiomeImmunity, MucosalAnimalsAntigens, BacterialBacteriaCell LineColitisDisease Models, AnimalEpithelial CellsFemaleHistocompatibility Antigens Class IIHost-Pathogen InteractionsIleumImmunoglobulin AMaleAntigens, BacterialHistocompatibility Antigens Class IIImmunoglobulin Aantigen processingdendritic cellH2-Ab1immunityintestinal epitheliamacrophageMHC class IImicrobiome
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.