ArticleCell reports2021
Inverse neurovascular coupling contributes to positive feedback excitation of vasopressin neurons during a systemic homeostatic challenge.
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Neurovascular coupling in the basolateral amygdala modulates negative emotions.Cell research · 2026Article
- Heart failure-induced reprogramming of salt-evoked neurovascular coupling in the rat hypothalamus.The Journal of physiology · 2026Article
- Hypothalamic insulin resistance in type 2 diabetes is localized to the posterior hypothalamus.JCI insight · 2026Article
- Neurovascular plasticity as a modulator of hypothalamic function.Reviews in endocrine & metabolic disorders · 2026Review
- Electrophysiological recording of hypothalamic brain regions in vivo using the transpharyngeal surgical approach in the rat.Journal of neuroendocrinology · 2026Review
- Blockade of Presynaptic αNeurochemical research · 2026Article
- Asymmetric blood flow within a shared capillary network links the nucleus of the solitary tract and area postrema.bioRxiv : the preprint server for biology · 2025Article
- Reduced osmoresponsiveness in magnocellular neuroendocrine neurones during chronic salt-loading.The Journal of physiology · 2025Article
- Navigating Central Oxytocin Transport: Known Realms and Uncharted Territories.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025Review
- Maternal high-salt intake induces sex-specific liver injury in offspring: integrative transcriptomic and therapeutic investigation.Frontiers in nutrition · 2025Article
- Abnormal neurovascular coupling exists in patients with peritoneal dialysis and hemodialysis: evidence from a multi-mode MRI study.Clinical kidney journal · 2025Article
- Blood flows from the SCN toward the OVLT within a new brain vascular portal pathway.Science advances · 2024Article
- Diurnal Variation of Brain Activity in the Human Suprachiasmatic Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Parallel trajectories in the discovery of the SCN-OVLT and pituitary portal pathways: Legacies of Geoffrey Harris.Journal of neuroendocrinology · 2023Review
- Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease.Molecular neurodegeneration · 2023Review
- Angiotensin II-Mediated Neuroinflammation in the Hippocampus Contributes to Neuronal Deficits and Cognitive Impairment in Heart Failure Rats.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Could respiration-driven blood oxygen changes modulate neural activity?Pflugers Archiv : European journal of physiology · 2023Review
- Microgeometrical dendritic factors predict electrical decoupling between somatic and dendritic compartments in magnocellular neurosecretory neurons.Frontiers in cellular neuroscience · 2023Article
- Neurovascular coupling: motive unknown.Trends in neurosciences · 2022Review
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Neurovascular coupling (NVC), the process that links neuronal activity to cerebral blood flow changes, has been mainly studied in superficial brain areas, namely the neocortex. Whether the conventional, rapid, and spatially restricted NVC response can be generalized to deeper and functionally diverse brain regions remains unknown. Implementing an approach for in vivo two-photon imaging from the ventral surface of the brain, we show that a systemic homeostatic challenge, acute salt loading, progressively increases hypothalamic vasopressin (VP) neuronal firing and evokes a vasoconstriction that reduces local blood flow. Vasoconstrictions are blocked by topical application of a VP receptor antagonist or tetrodotoxin, supporting mediation by activity-dependent, dendritically released VP. Salt-induced inverse NVC results in a local hypoxic microenvironment, which evokes positive feedback excitation of VP neurons. Our results reveal a physiological mechanism by which inverse NVC responses regulate systemic homeostasis, further supporting the notion of brain heterogeneity in NVC responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.