Observational studyAmerican journal of respiratory and critical care medicine2022
Two New Neutrophil Subsets Define a Discriminating Sepsis Signature.
Open access · greenAbstract readObservational Study
In one paragraph
Observational study in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 87 citations in OpenAlex.
- Identification of novel sepsis-related neutrophil subsets and surface markers for clinical diagnosis and outcome.Virulence · 2026Article
- CFTR modulators exert subset-specific phenotype remodeling on circulating neutrophils in cystic fibrosis.ImmunoHorizons · 2026Article
- Impact of intravitreal bevacizumab on immune cells in neovascular age related macular degeneration.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Neutrophil Irgm1 ameliorates sepsis-induced myocardial dysfunction by promoting Alox15 degradation.Redox biology · 2026Article
- Neutrophil Heterogeneity: Molecules to Cellular Behavior.Life (Basel, Switzerland) · 2026Review
- Dysregulation of Neutrophil-Endothelial Communication in Sepsis: Mechanisms and Therapeutic Perspectives.Cells · 2026Review
- Immunology of Sepsis.Clinics in chest medicine · 2026Review
- Context-specific regulatory genetic variation in MTOR dampens neutrophil-T cell crosstalk in pneumonia-associated sepsis.Nature communications · 2026Article
- Neutrophil in sepsis: functional aberration and regulated cell death.Frontiers in immunology · 2026Review
- Single-cell immune landscape of acute kidney injury after cardiac surgery with cardiopulmonary bypass.Renal failure · 2025Article
- Multi‑omics reveal neutrophil heterogeneity in sepsis (Review).International journal of molecular medicine · 2025Review
- Biomaterial-mediated macrophage polarization remodeling and sequential regulation: a potential strategy in bone infections treatment.Bone research · 2025Review
- Spatiotemporal regulation of neutrophil heterogeneity in health and disease.Human molecular genetics · 2025Review
- Target neutrophil heterogeneity and plasticity in cancer.Journal of hematology & oncology · 2025Review
- Unraveling immunosenescence in sepsis: from cellular mechanisms to therapeutics.Cell death & disease · 2025Review
- High-dimensional spectral flow cytometry of activation and phagocytosis by peripheral human polymorphonuclear leukocytes.Journal of leukocyte biology · 2025Article
- Low expression of CD39 on monocytes predicts poor survival in sepsis patients.Journal of intensive care · 2025Article
- Dysregulation of neutrophil in sepsis: recent insights and advances.Cell communication and signaling : CCS · 2025Review
- CD121b-positive neutrophils predict immunosuppression in septic shock.Frontiers in immunology · 2025Article
- The dual role of neutrophils in sepsis-associated liver injury.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Aïda Meghraoui-KheddarSorbonne Université-Institut National de la Santé et de la Recherche Médicale-Centre National de la Recherche Scientifique, Centre d'Immunologie et des Maladies Infectieuses, Paris, France.ORCID 0000-0002-7440-5495
Benjamin G ChoustermanDispositif Minimum d'Urgence Parabol, Fédération Hospitalo-Universitaire Promice, Service d'Anesthésie et de Soins Intensifs, Centre Hospitalier Universitaire Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France.
Noëlline GuillouSorbonne Université-Institut National de la Santé et de la Recherche Médicale-Centre National de la Recherche Scientifique, Centre d'Immunologie et des Maladies Infectieuses, Paris, France.
Sierra M BaroneDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee.
Samuel GranjeaudU1068/UM 105/UMR7258: Marseille Cancer Research Center, National Institute of Health and Medical Research-Paoli-Calmettes Institute-Aix-Marseille University-National Center for Scientific Research, Marseille, France.
Helene ValletSorbonne Université-Institut National de la Santé et de la Recherche Médicale-Centre National de la Recherche Scientifique, Centre d'Immunologie et des Maladies Infectieuses, Paris, France.
Aurélien CorneauCytométrie Pitié-Salpêtrière, UMS037: Production et Analyse de Données en Sciences de la Vie et en Santé, Sorbonne Université, Paris, France; and.
Karim GuessousDispositif Minimum d'Urgence Parabol, Fédération Hospitalo-Universitaire Promice, Service d'Anesthésie et de Soins Intensifs, Centre Hospitalier Universitaire Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France.
Charles de RoquetailladeDispositif Minimum d'Urgence Parabol, Fédération Hospitalo-Universitaire Promice, Service d'Anesthésie et de Soins Intensifs, Centre Hospitalier Universitaire Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France.ORCID 0000-0002-3333-4686
Alexandre BoissonnasSorbonne Université-Institut National de la Santé et de la Recherche Médicale-Centre National de la Recherche Scientifique, Centre d'Immunologie et des Maladies Infectieuses, Paris, France.
Jonathan M IrishDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee.
Christophe CombadièreSorbonne Université-Institut National de la Santé et de la Recherche Médicale-Centre National de la Recherche Scientifique, Centre d'Immunologie et des Maladies Infectieuses, Paris, France.
Sorbonne Université · FRHôpital Lariboisière · FRVanderbilt University · USCentre de Recherche en Cancérologie de Marseille · FR
Funding
Single Cell Methods for Bioeffector Discovery and AnalysisR01CA226833 · NCI · VANDERBILT UNIVERSITY · PI BRIAN O BACHMANN, Jonathan Michael Irish · 2019 to 2026
$6.1MNCI NIH HHS R01 CA226833
Abstract
PubMed holds no abstract for this paper.
Indexed as
B7-H1 AntigenBiomarkersCase-Control StudiesClinical Decision RulesDiagnosis, DifferentialFlow CytometryHumansInterleukin-3 Receptor alpha SubunitLinear ModelsLongitudinal StudiesNeutrophilsReceptors, IgGSensitivity and SpecificitySepsisSeverity of Illness IndexB7-H1 AntigenBiomarkersCD274 protein, humanIL3RA protein, humanInterleukin-3 Receptor alpha SubunitReceptors, IgGCD123diagnosisneutrophilsPD-L1sepsis
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.