Evidence map›Paper›PMID 34731491›Full record

ArticleThe Journal of pathology2022

BCG invokes superior STING-mediated innate immune response over radiotherapy in a carcinogen murine model of urothelial cancer.

Kara A Lombardo, Aleksandar Obradovic, Alok Kumar Singh, James L Liu, Gregory Joice, Max Kates, William Bishai, David McConkey, Alcides Chaux, Marie-Lisa Eich and 6 more

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Kara A LombardoDepartment of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.ORCID 0000-0001-7894-4253
Aleksandar Obradovic *Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.
Alok Kumar Singh *Center for Tuberculosis Research, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
James L LiuDepartment of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Gregory JoiceDepartment of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Max KatesDepartment of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
William BishaiCenter for Tuberculosis Research, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.ORCID 0000-0002-8734-4118
David McConkeyGreenberg Bladder Cancer Institute, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Alcides ChauxDepartment of Scientific Research, School of Postgraduate Studies, Norte University, Asunción, Paraguay.
Marie-Lisa EichDepartment of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA.
M Katayoon RezaeiDepartment of Pathology, George Washington University, Washington, DC, USA.
George J NettoDepartment of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA.
Charles G DrakeCenter for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Phuoc TranDepartment of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Andres MatosoDepartment of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Trinity J BivalacquaDepartment of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Johns Hopkins University · USColumbia University Irving Medical Center · USUniversity of Alabama at Birmingham · USGeorge Washington University · USUniversidad del Norte · PY

Funding

A STINGing vaccine for TBR01AI155346 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BISHAI, WILLIAM RAMSES, MEHRA, SMRITI · 2020 to 2024
$4.9M
Discovering Network-Based Drivers of Single-Cell Transcriptional State in Tumor Immune Microenvironment to Reveal Immuno-Therapeutic Targets and Treatment SynergiesF30CA260765 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI OBRADOVIC, ALEKSANDAR ZORAN · 2021 to 2022
$98k
NCI NIH HHS F30 CA260765NIAID NIH HHS R01 AI155346
6 · The paper itself

Abstract

Radiation and bacillus Calmette-Guérin (BCG) instillations are used clinically for treatment of urothelial carcinoma, but the precise mechanisms by which they activate an immune response remain elusive. The role of the cGAS-STING pathway has been implicated in both BCG and radiation-induced immune response; however, comparison of STING pathway molecules and the immune landscape following treatment in urothelial carcinoma has not been performed. We therefore comprehensively analyzed the local immune response in the bladder tumor microenvironment following radiotherapy and BCG instillations in a well-established spontaneous murine model of urothelial carcinoma to provide insight into activation of STING-mediated immune response. Mice were exposed to the oral carcinogen, BBN, for 12 weeks prior to treatment with a single 15 Gy dose of radiation or three intravesical instillations of BCG (1 × 10

Indexed as

ImmunotherapyRadiation DosageAdministration, IntravesicalAnimalsAntineoplastic AgentsBCG VaccineFemaleHumansImmunity, InnateInflammation MediatorsLymphocytes, Tumor-InfiltratingMembrane ProteinsMiceMice, Inbred C57BLSTING ProteinT-LymphocytesAntineoplastic AgentsBCG VaccineInflammation MediatorsMembrane ProteinsSTING1 protein, humanSting1 protein, mouseSTING ProteinBCGbladder cancerinnate immunityinterferonmacrophagesradiotherapySTINGT-cellsTrex-1tumor immune microenvironment

Identifiers

PMID34731491
PMCPMC8738146
OpenAlexW3210000880

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.