Evidence map›Paper›PMID 34731233›Full record

ReviewAnesthesiology2021

Sleep, Pain, and Cognition: Modifiable Targets for Optimal Perioperative Brain Health.

Brian P O'Gara, Lei Gao, Edward R Marcantonio, Balachundhar Subramaniam

2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Anesthesiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 93 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 5 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06052397 recruitingnot on this mapstarted 2023, after this paper: background citation

Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium

TypeobservationalSponsorMassachusetts General HospitalRan2023 to 2027Enrolled150ConditionsDelirium, Postoperative, Cognitive Decline, Dementia
NCT06696404 nacompletednot on this mapstarted 2024, after this paper: background citation

The Role of Nerve Block-Constructed Precision Anesthesia on Perioperative Organ Protection in Hip Surgery

TypeinterventionalSponsorShanghai Jiao Tong University Affiliated Sixth People's HospitalRan2024 to 2025Enrolled90ConditionsElderly (People Aged 65 or More), Hip Fracture, Delirium - Postoperative, Organ ProtectionArmsCombined Lumbar Plexus and Sacral Plexus Block, iliac fascial block, spinal anesthesia
3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 5 syntheses or guidelines pooled it, 123 citations in OpenAlex.

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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Brian P O'GaraDepartments of Anesthesiology, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Lei Gaothe Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Edward R MarcantonioMedicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Balachundhar SubramaniamDepartments of Anesthesiology, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Beth Israel Deaconess Medical Center · USHarvard University · US

Funding

The Role of Inflammation in the Pathophysiology of Delirium and its Associated Long-Term Cognitive DeclineP01AG031720 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K. · 2010 to 2022
$26.7M
Scheduled Prophylactic 6-hourly IV Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients (PANDORA) - EEG Administrative SupplementR01AG065554 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MARCANTONIO, EDWARD R, SUBRAMANIAM, BALACHUNDHAR · 2019 to 2025
$7.4M
Mid-Career Mentoring Award for Patient-Oriented Research in AgingK24AG035075 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MARCANTONIO, EDWARD R · 2010 to 2021
$1.9M
Circadian Multiscale Activity Regulation and the Risk for Delirium in Elderly Hospitalized PatientsR03AG067985 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GAO, LEI · 2020 to 2021
$268k
NIA NIH HHS K24 AG035075NIA NIH HHS P01 AG031720NIA NIH HHS R01 AG065554NIA NIH HHS R03 AG067985
6 · The paper itself

Abstract

The prevention of perioperative neurocognitive disorders is a priority for patients, families, clinicians, and researchers. Given the multiple risk factors present throughout the perioperative period, a multicomponent preventative approach may be most effective. The objectives of this narrative review are to highlight the importance of sleep, pain, and cognition on the risk of perioperative neurocognitive disorders and to discuss the evidence behind interventions targeting these modifiable risk factors. Sleep disruption is associated with postoperative delirium, but the benefit of sleep-related interventions is uncertain. Pain is a risk factor for postoperative delirium, but its impact on other postoperative neurocognitive disorders is unknown. Multimodal analgesia and opioid avoidance are emerging as best practices, but data supporting their efficacy to prevent delirium are limited. Poor preoperative cognitive function is a strong predictor of postoperative neurocognitive disorder, and work is ongoing to determine whether it can be modified to prevent perioperative neurocognitive disorders.

Indexed as

BrainCircadian RhythmCognitionHumansPainPerioperative CarePostoperative ComplicationsRisk FactorsSleepSleep Wake Disorders

Identifiers

PMID34731233
PMCPMC8578455
OpenAlexW3208872962

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.