Evidence map›Paper›PMID 34731088›Full record

ArticleAging2021

Integrated analysis of expression, prognostic value and immune infiltration of GSDMs in hepatocellular carcinoma.

Kuan Hu, Zhijie Xu, Lei Yao, Yuanliang Yan, Lei Zhou, Juanni Li

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Review
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  5. Article
  6. The gasdermin family: emerging therapeutic targets in diseases.Signal transduction and targeted therapy · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. The role of pyroptosis in hepatocellular carcinoma.Cellular oncology (Dordrecht, Netherlands) · 2023
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kuan HuDepartment of Hepatobiliary Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Zhijie XuDepartment of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Lei YaoDepartment of Hepatobiliary Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Yuanliang YanDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Lei ZhouDepartment of Anesthesiology, Third Xiangya Hospital of Central South University, Changsha 410008, Hunan, China.
Juanni LiDepartment of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Central South University · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Six Gasdermins (GSDM) family members participate in various biological processes especially pyroptosis, as well as in the initiation and development of many types of cancer. However, the systematic analysis of the GSDM family in hepatocellular carcinoma (HCC) is lacking. In this study, several bioinformatics databases were recruited to analyze the roles of the GSDMs in differential expression, prognostic correlation, functional enrichment exploration, immune modulation, genetic alterations, and methylated modification in patients with HCC. Consequently, the mRNA expression of all the six GSDMs was accordantly increased in HCC, while only the protein expressions of GSDMB, GSDMD, and GSDME were apparently increased in HCC tissue. The expression of all the GSDMs (except GSDMA) was significantly higher in tumor stage 1-3 subgroups, compared with that in normal subgroups. Higher GSDME expression was significantly associated with shorter overall survival (OS) and disease specific survival (DSS) in patients with HCC. GSDMD had the highest genetic alteration rate among the GSDMs. The three signal pathways which were most likely related to GSDMs-associated molecules were the cell adhesion, growth regulation, and hormone metabolic process. The majority of GSDMs members were positively correlated with the infiltration of B cells, neutrophils, and dendritic cells, however negatively correlated with macrophage. All of the six GSDM members showed remarkably decreased methylation levels in HCC tissues. In conclusion, the GSDM family (especially GSDME) had the potential to become essential biomarkers to better improve the diagnosis and prognosis of HCC, as well as provided insight for the development of therapeutic targets.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsNeoplasm ProteinsCell Line, TumorDatabases, GeneticGasderminsGene Expression Regulation, NeoplasticHumansNeoplasm InvasivenessPrognosisTranscriptomeGasderminsGSDMA protein, humanNeoplasm Proteinsexpression profilesGSDM familyhepatocellular carcinomaimmune infiltrationprognosis

Identifiers

PMID34731088
PMCPMC8610125
OpenAlexW3209059346

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.