ArticleScience translational medicine2021
Truncated titin proteins in dilated cardiomyopathy.
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
8.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Research landscape of genetics in dilated cardiomyopathy: insight from a bibliometric analysis.Frontiers in cardiovascular medicine · 2024Pooled it
- Functional analysis ofMolecular therapy. Nucleic acids · 2026Article
- Nx3 Is a Z-Disk Structural and Signaling Hub That Is Reduced in Heart Failure.Circulation research · 2026Article
- Therapeutic upregulation of gene expression in inherited cardiomyopathies from current approaches to future directions.Nature cardiovascular research · 2026Review
- Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients with TTN mutations.Stem cell research · 2026Article
- Variant Site-Specific Natural History of Titin-Induced Cardiomyopathy: An International Multicenter Registry.Circulation. Genomic and precision medicine · 2026Article
- A titin truncating variant linked to atrial fibrillation increases atrial profibrotic signalling and cholinergic sensitivity.Cardiovascular research · 2026Article
- Review
- RNA-Based Therapies for Treating Monogenic Cardiomyopathies.The Canadian journal of cardiology · 2026Review
- Truncating Variants inJournal of the American Heart Association · 2026Article
- Location-Dependent Differences in Cardiac and Skeletal Muscle Dysfunction Associated With Truncating Titin (Circulation research · 2026Article
- Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients harbouring TTN mutations.Stem cell research · 2025Article
- Titin-Truncating variants predispose to dilated cardiomyopathy in populations genetically similar to african and european reference populations.PLoS genetics · 2025Article
- TTN:c.12478del in proximal I-band of titin represents a common molecular cause of dilated cardiomyopathy in Slovenian patients.Orphanet journal of rare diseases · 2025Article
- Regulation of TTN as a mechanism of and treatment for heart failure.The Journal of clinical investigation · 2025Article
- Proteomic Profiling Towards a Better Understanding of Genetic Based Muscular Diseases: The Current Picture and a Look to the Future.Biomolecules · 2025Review
- Pathomechanisms of Monoallelic variants in TTN causing skeletal muscle disease.Human molecular genetics · 2024Article
- A Titin Truncating Variant Causing a Dominant Myopathy With Cardiac Involvement in a Large Family: The Exception That Proves the Rule.Neurology. Genetics · 2024Article
- The Genetic Factors Influencing Cardiomyopathies and Heart Failure across the Allele Frequency Spectrum.Journal of cardiovascular translational research · 2024Review
- Titin truncating variants, cardiovascular risk factors and the risk of atrial fibrillation and heart failure.Nature cardiovascular research · 2024Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
15 authors at 1 institution in 1 country.
Quentin McAfeeCardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.ORCID 0000-0002-1154-0331
Christina Yingxian ChenDepartment of Physiology, Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.ORCID 0000-0002-8013-1515
Yifan YangCardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.ORCID 0000-0002-5381-8143
Matthew A CaporizzoDepartment of Physiology, Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.ORCID 0000-0002-9997-5718
Michael MorleyCardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.ORCID 0000-0002-0958-7376
Apoorva BabuCardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.ORCID 0000-0003-3661-5261
Sunhye JeongCardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.
Jeffrey BrandimartoCardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.
Kenneth C BediCardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.
Emily FlamCardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.ORCID 0000-0001-6262-1126
Joseph CesareCardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.ORCID 0000-0002-5569-1422
Thomas P CappolaCardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.ORCID 0000-0002-9630-7204
Kenneth MarguliesCardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.ORCID 0000-0002-8093-4465
Benjamin ProsserDepartment of Physiology, Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.
Zolt AranyCardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.ORCID 0000-0003-1368-2453
University of Pennsylvania · US
Funding
Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)P30AR069619 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOUIS J SOSLOWSKY · 2016 to 2026
$9.1MIntegrative genomics of human heart failureR01HL105993 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ASHLEY, EUAN A, CAPPOLA, THOMAS P. · 2011 to 2014
$8.9MTraining in Muscle Biology and Muscle DiseaseT32AR053461 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI OSTAP, E. MICHAEL · 2006 to 2025
$4.9MDetyrosinated microtubules in cardiomyocyte mechanicsR01HL133080 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Benjamin Lears Prosser · 2016 to 2026
$4.7MMTSS1 in Myocardial DiseaseR01HL141232 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI THOMAS P. CAPPOLA, Scott Michael Damrauer · 2019 to 2026
$4.7MBranched chain amino acids in heart failureR01HL152446 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Zoltan P Arany · 2020 to 2026
$3.7MMECHANISMS OF IMPROVED DIASTOLIC FUNCTION IN HUMAN HEARTR01AG017022 · NIA · UNIVERSITY OF PENNSYLVANIA · PI MARGULIES, KENNETH BER · 1998 to 2007
$2.9MEndogenous Cardiac Repair in HumansR01HL089847 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MARGULIES, KENNETH BER · 2009 to 2012
$1.9MsFlt and Metabolic Mechanisms of Peripartium CardiomyopathyR01HL126797 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ARANY, ZOLTAN P · 2016 to 2019
$1.6MNHLBI NIH HHS R01 HL089847NHLBI NIH HHS R01 HL105993NHLBI NIH HHS R01 HL126797NHLBI NIH HHS R01 HL133080NHLBI NIH HHS R01 HL141232NHLBI NIH HHS R01 HL152446NIAMS NIH HHS P30 AR069619NIAMS NIH HHS T32 AR053461NIA NIH HHS R01 AG017022
Abstract
Truncating variants in
Indexed as
Cardiomyopathy, DilatedConnectinAdultAllelesHumansMyocytes, CardiacConnectinTTN protein, human
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.