ArticleScience translational medicine2021
Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to
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Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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83citing papers in PubMed
13.7field-weighted citation impact, top 1% of its field
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Who cites it
83 citing papers in PubMed, 119 citations in OpenAlex.
- Functional analysis ofMolecular therapy. Nucleic acids · 2026Article
- Nx3 Is a Z-Disk Structural and Signaling Hub That Is Reduced in Heart Failure.Circulation research · 2026Article
- Therapeutic upregulation of gene expression in inherited cardiomyopathies from current approaches to future directions.Nature cardiovascular research · 2026Review
- Sarcomere dynamic instability and stochastic heterogeneity drive robust cardiomyocyte contraction.eLife · 2026Article
- Review
- Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients with TTN mutations.Stem cell research · 2026Article
- SGLT2 inhibition improves sarcomere contractile dysfunction in human models of dilated cardiomyopathy.Journal of translational medicine · 2026Article
- Variant Site-Specific Natural History of Titin-Induced Cardiomyopathy: An International Multicenter Registry.Circulation. Genomic and precision medicine · 2026Article
- Vein graft failure: Pathophysiology, detection, prevention and emerging therapeutic strategies.Pharmacological reviews · 2026Review
- A titin truncating variant linked to atrial fibrillation increases atrial profibrotic signalling and cholinergic sensitivity.Cardiovascular research · 2026Article
- Selective titin cleavage disrupts cardiac mechanical homeostasis to drive heart failure and fibrosis.Nature cardiovascular research · 2026Article
- Review
- Models of the human heart for biomedical research: Opportunities and challenges.Physiological reports · 2026Review
- Truncating Variants inJournal of the American Heart Association · 2026Article
- Mending the Achilles heels of titin in cardiac and musculoskeletal disease.Biophysical reviews · 2026Review
- Location-Dependent Differences in Cardiac and Skeletal Muscle Dysfunction Associated With Truncating Titin (Circulation research · 2026Article
- GDIv2: improving variant selection from human exomes.Bioinformatics advances · 2026Article
- Genetic Spectrum, Clinical Characteristics, and Molecular Pathogenesis of Hypertrophic Cardiomyopathy Requiring Heart Transplantation.Journal of cardiovascular development and disease · 2025Article
- Integrating Senescence and Oxidative Stress in Cardiac Disease.International journal of molecular sciences · 2025Review
- Titin Cardiomyopathy, Emerging Evidence: More Than A Big Heart.Current cardiology reports · 2025Review
23 more citing papers are in PubMed but not listed here.
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Authors and funding
28 authors at 9 institutions in 5 countries.
Andrey FominClinic for Cardiology and Pneumology, University Medical Center, 37075 Göttingen, Germany.ORCID 0000-0001-5578-6977
Anna GärtnerErich and Hanna Klessmann Institute, Heart and Diabetes Centre NRW, University Hospital of the Ruhr-University Bochum, 32545 Bad Oeynhausen, Germany.ORCID 0000-0001-6899-7693
Lukas CyganekClinic for Cardiology and Pneumology, University Medical Center, 37075 Göttingen, Germany.ORCID 0000-0001-9120-1382
Malte TiburcyGerman Centre for Cardiovascular Research, 10785 Berlin, partner site Göttingen, Germany.ORCID 0000-0002-6942-6275
Izabela TuletaDepartment of Cardiology I, Coronary, Peripheral Vascular Disease and Heart Failure, 48149 University Hospital Münster, Münster, Germany.
Luisa WellersInstitute of Physiology II, University of Münster, 48149 Münster, Germany.
Lina FolscheInstitute of Physiology II, University of Münster, 48149 Münster, Germany.ORCID 0000-0003-3752-170X
Anastasia J HobbachDepartment of Cardiology I, Coronary, Peripheral Vascular Disease and Heart Failure, 48149 University Hospital Münster, Münster, Germany.ORCID 0000-0001-6421-8429
Marion von Frieling-SalewskyInstitute of Physiology II, University of Münster, 48149 Münster, Germany.
Andreas UngerInstitute of Physiology II, University of Münster, 48149 Münster, Germany.
Anna HuckeInstitute of Physiology II, University of Münster, 48149 Münster, Germany.ORCID 0000-0002-2044-2602
Franziska KoserInstitute of Physiology II, University of Münster, 48149 Münster, Germany.
Astrid KassnerErich and Hanna Klessmann Institute, Heart and Diabetes Centre NRW, University Hospital of the Ruhr-University Bochum, 32545 Bad Oeynhausen, Germany.
Katharina SielemannErich and Hanna Klessmann Institute, Heart and Diabetes Centre NRW, University Hospital of the Ruhr-University Bochum, 32545 Bad Oeynhausen, Germany.ORCID 0000-0002-4022-8531
Katrin Streckfuß-BömekeClinic for Cardiology and Pneumology, University Medical Center, 37075 Göttingen, Germany.ORCID 0000-0001-5137-7228
Gerd HasenfussClinic for Cardiology and Pneumology, University Medical Center, 37075 Göttingen, Germany.ORCID 0000-0002-5942-361X
Alexander GoedelFirst Medical Department, Cardiology, Technical University of Munich, 81675 Munich, Germany.ORCID 0000-0002-5980-2257
Karl-Ludwig LaugwitzFirst Medical Department, Cardiology, Technical University of Munich, 81675 Munich, Germany.
Alessandra MorettiFirst Medical Department, Cardiology, Technical University of Munich, 81675 Munich, Germany.ORCID 0000-0001-5782-7832
Jan F GummertErich and Hanna Klessmann Institute, Heart and Diabetes Centre NRW, University Hospital of the Ruhr-University Bochum, 32545 Bad Oeynhausen, Germany.
Cristobal G Dos RemediosVictor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia.ORCID 0000-0003-1052-7490
Holger ReineckeDepartment of Cardiology I, Coronary, Peripheral Vascular Disease and Heart Failure, 48149 University Hospital Münster, Münster, Germany.ORCID 0000-0002-4515-1609
Ralph KnöllDepartment of Medicine, Integrated Cardio Metabolic Centre (ICMC), Heart and Vascular Theme, Karolinska Institute, S-17177 Stockholm, Sweden.ORCID 0000-0001-8871-112X
Sebastiaan van HeeschCardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.ORCID 0000-0001-9593-1980
Norbert HubnerCardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.ORCID 0000-0002-1218-6223
Wolfram H ZimmermannGerman Centre for Cardiovascular Research, 10785 Berlin, partner site Göttingen, Germany.ORCID 0000-0003-1190-4040
Hendrik MiltingErich and Hanna Klessmann Institute, Heart and Diabetes Centre NRW, University Hospital of the Ruhr-University Bochum, 32545 Bad Oeynhausen, Germany.ORCID 0000-0001-9722-0007
Wolfgang A LinkeClinic for Cardiology and Pneumology, University Medical Center, 37075 Göttingen, Germany.ORCID 0000-0003-0801-3773
University of Münster · DEHeart and Diabetes Center North Rhine-Westphalia · DEGerman Centre for Cardiovascular Research · DEUniversitätsmedizin Göttingen · DEUniversity Hospital Münster · DEMax Delbrück Center · DEIntegrated Cardio Metabolic Centre · SEKarolinska Institutet · SEVictor Chang Cardiac Research Institute · AU
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterozygous truncating variants in
Indexed as
CardiomyopathiesConnectinHeart TransplantationInduced Pluripotent Stem CellsHaploinsufficiencyHumansMutationMyocytes, CardiacTissue DonorsConnectinTTN protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.