ArticleScience advances2021
Excitatory-inhibitory balance modulates the formation and dynamics of neuronal assemblies in cortical networks.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- Excitatory and inhibitory networks diverge following early blindness.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Enriched experience increases reciprocal synaptic connectivity and coding sparsity in higher-order cortex.Science advances · 2026Article
- Subtyping OCD based on individual symptom networks: subtype-specific neural dynamics and morphometric similarity linked to molecular profiles.Molecular psychiatry · 2026Article
- Transcriptomics and proteomics of projection neurons in a circuit linking hippocampus with dorsolateral prefrontal cortex in the human brain.bioRxiv : the preprint server for biology · 2026Article
- Article
- Correlative voltage imaging and cryo-electron tomography bridge neuronal activity and molecular structure.Nature communications · 2025Article
- Enriched experience increases reciprocal synaptic connectivity and coding sparsity in higher-order cortex.bioRxiv : the preprint server for biology · 2025Article
- From initial formation to developmental refinement: GABAergic inputs shape neuronal subnetworks in the primary somatosensory cortex.iScience · 2025Article
- Temporal Lobe Epilepsy Perturbs the Brain-Wide Excitation-Inhibition Balance: Associations with Microcircuit Organization, Clinical Parameters, and Cognitive Dysfunction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Regulation of GABAergic neurotransmission by purinergic receptors in brain physiology and disease.Purinergic signalling · 2025Review
- Geometry and dynamics of representations in a precisely balanced memory network related to olfactory cortex.eLife · 2025Article
- Metastable dynamics emerge from local excitatory-inhibitory homeostasis in the cortex at rest.Network neuroscience (Cambridge, Mass.) · 2025Article
- Excitatory-inhibitory homeostasis and bifurcation control in the Wilson-Cowan model of cortical dynamics.PLoS computational biology · 2025Article
- Enhanced fear memory after social defeat in mice is dependent on interleukin-1 receptor signaling in glutamatergic neurons.Molecular psychiatry · 2024Article
- A neural basis for learning sequential memory in brain loop structures.Frontiers in computational neuroscience · 2024Article
- Excitation/Inhibition balance relates to cognitive function and gene expression in temporal lobe epilepsy: a high density EEG assessment with aperiodic exponent.Brain communications · 2024Article
- Whole-Brain Evaluation of Cortical Microconnectomes.eNeuro · 2023Article
- Myelination and excitation-inhibition balance synergistically shape structure-function coupling across the human cortex.Nature communications · 2023Article
- Voltage-Gated NaLife (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Repetitive activation of subpopulations of neurons leads to the formation of neuronal assemblies, which can guide learning and behavior. Recent technological advances have made the artificial induction of these assemblies feasible, yet how various parameters of induction can be optimized is not clear. Here, we studied this question in large-scale cortical network models with excitatory-inhibitory balance. We found that the background network in which assemblies are embedded can strongly modulate their dynamics and formation. Networks with dominant excitatory interactions enabled a fast formation of assemblies, but this was accompanied by recruitment of other non-perturbed neurons, leading to some degree of nonspecific induction. On the other hand, networks with strong excitatory-inhibitory interactions ensured that the formation of assemblies remained constrained to the perturbed neurons, but slowed down the induction. Our results suggest that these two regimes can be suitable for computational and cognitive tasks with different trade-offs between speed and specificity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.