ArticleScience advances2021
Noncoding loci without epigenomic signals can be essential for maintaining global chromatin organization and cell viability.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Towards efficient perturbation for the noncoding genome.Nature communications · 2026Article
- Prime editor-based high-throughput screening reveals functional synonymous mutations in human cells.Nature biotechnology · 2026Article
- chromIDEAS reveals epigenetic dynamics via multi-dimensional clustering of chromatin states.Nucleic acids research · 2026Article
- Identification of Disease-miRNA Networks Across Different Human Complex Diseases Using SWIM and MIENTURNET Tools.Methods in molecular biology (Clifton, N.J.) · 2026Article
- A fuzzy sequencer for rapid DNA fragment counting and genotyping.Nature biomedical engineering · 2025Article
- Endogenous fine-mapping and prioritization of functional regulatory elements in complex genetic loci.Cell genomics · 2025Article
- A one-base therapeutic insertion in the HBG2 distal promoter reactivates γ-globin expression.Experimental hematology & oncology · 2025Article
- Massively parallel interrogation of human functional variants modulating cancer immunosurveillance.Signal transduction and targeted therapy · 2025Article
- Differential impact of quiescent non-coding loci on chromatin entropy.Nucleic acids research · 2024Article
- MAE-seq refines regulatory elements across the genome.Nucleic acids research · 2024Article
- Landscape of enhancer disruption and functional screen in melanoma cells.Genome biology · 2023Article
- Characterization of network hierarchy reflects cell state specificity in genome organization.Genome research · 2023Article
- Regulation associated modules reflect 3D genome modularity associated with chromatin activity.Nature communications · 2022Article
- Regulatory elements can be essential for maintaining broad chromatin organization and cell viability.Nucleic acids research · 2022Article
- Towards key scientific questions in the diagnosis and treatment of rare diseases: Summary from the 297th Meeting of the Shuangqing Forum.Zoological research · 2022Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Most noncoding regions of the human genome do not harbor any annotated element and are even not marked with any epigenomic or protein binding signal. However, an overlooked aspect of their possible role in stabilizing 3D chromatin organization has not been extensively studied. To illuminate their structural importance, we started with the noncoding regions forming many 3D contacts (referred to as hubs) and performed a CRISPR library screening to identify dozens of hubs essential for cell viability. Hi-C and single-cell transcriptomic analyses showed that their deletion could significantly alter chromatin organization and affect the expressions of distal genes. This study revealed the 3D structural importance of noncoding loci that are not associated with any functional element, providing a previously unknown mechanistic understanding of disease-associated genetic variations (GVs). Furthermore, our analyses also suggest a possible approach to develop therapeutics targeting disease-specific noncoding regions that are critical for disease cell survival.
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Registered trials
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