Evidence map›Paper›PMID 34731000›Full record

ArticleScience advances2021

Deletion of

Hande Karahan, Daniel C Smith, Byungwook Kim, Luke C Dabin, Md Mamun Al-Amin, H R Sagara Wijeratne, Taylor Pennington, Gonzalo Viana di Prisco, Brianne McCord, Peter Bor-Chian Lin and 6 more

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Aberrant phase separation from a rare ABI3 mutation drives microglial dysfunction and Alzheimer's risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Article
  3. Article
  4. Abi3Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Microglial phagocytosis in Alzheimer disease.Nature reviews. Neurology · 2026
    Review
  9. Article
  10. Deletion of neuronal Idol ameliorates Alzheimer's disease-related pathologies via APOE receptors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hande KarahanStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-3192-7362
Daniel C SmithStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-2910-6533
Byungwook KimStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-8390-7713
Luke C DabinStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-6365-291X
Md Mamun Al-AminStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-4234-7152
H R Sagara WijeratneStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-8209-5626
Taylor PenningtonStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Gonzalo Viana di PriscoStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Brianne McCordStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Peter Bor-Chian LinStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-8954-9045
Yuxin LiDepartments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0001-9739-9860
Junmin PengDepartments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0003-0472-7648
Adrian L OblakStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-1210-8791
Shaoyou ChuDivision of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Brady K AtwoodStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-7441-2724
Jungsu KimStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-6931-8581

Funding

Role of microRNA-33 in Alzheimer's diseaseR01AG053500 · NIA · MAYO CLINIC JACKSONVILLE · PI KIM, JUNGSU · 2016 to 2020
$2.0M
Role of LDLR in regulating metabolism of Apolipoprotein E and Amyloid-betaR01AG053242 · NIA · MAYO CLINIC JACKSONVILLE · PI KIM, JUNGSU · 2016 to 2020
$2.0M
The role of aging-associated microRNAs in Alzheimer's diseaseR01AG054102 · NIA · MAYO CLINIC JACKSONVILLE · PI KIM, JUNGSU · 2016 to 2020
$2.0M
microRNA-758-3p in cognition and Alzheimer's DiseaseR21AG050804 · NIA · MAYO CLINIC JACKSONVILLE · PI KIM, JUNGSU · 2016 to 2017
$430k
NIA NIH HHS R01 AG053242NIA NIH HHS R01 AG053500NIA NIH HHS R01 AG054102NIA NIH HHS R21 AG050804
6 · The paper itself

Abstract

Recently, large-scale human genetics studies identified a rare coding variant in the

Identifiers

PMID34731000
PMCPMC8565913

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.