Evidence map›Paper›PMID 34730869›Full record

ArticleEnvironmental toxicology2022

ROS generation is involved in titanium dioxide nanoparticle-induced AP-1 activation through p38 MAPK and ERK pathways in JB6 cells.

Lu Kong, Tabatha Barber, Joni Aldinger, Linda Bowman, Stephen Leonard, Jinshun Zhao, Min Ding

Abstract read
In one paragraph

Article in Environmental toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Optimizing Sunscreen Safety: The Impact of TiONanomaterials (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Assessing the Cytotoxicity of TiOBiological trace element research · 2023
    Article
  10. [Extraction of Extracelluar Vesicles Derived fromSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023
    Article
  11. Histone MethyltransferaseAntioxidants (Basel, Switzerland) · 2022
    Article
  12. Intestinal Microecology of Mice Exposed to TiOFoods (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lu KongKey Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing, China.
Tabatha BarberToxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.
Joni AldingerToxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.
Linda BowmanToxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.
Stephen LeonardPathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.
Jinshun ZhaoToxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.
Min DingToxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.

Funding

Intramural CDC HHS CC999999National Nature Science Foundation of Chinathe National Important Project on Scientific Research of China
6 · The paper itself

Abstract

Titanium dioxide (TiO

Indexed as

NanoparticlesTranscription Factor AP-1AnimalsExtracellular Signal-Regulated MAP KinasesJNK Mitogen-Activated Protein KinasesMAP Kinase Signaling SystemMicep38 Mitogen-Activated Protein KinasesRatsReactive Oxygen SpeciesTitaniumExtracellular Signal-Regulated MAP KinasesJNK Mitogen-Activated Protein Kinasesp38 Mitogen-Activated Protein KinasesReactive Oxygen SpeciesTitaniumtitanium dioxideTranscription Factor AP-1activator protein-1 (AP-1)JB6 cellsmitogen-activated protein kinases (MAPKs)reactive oxygen species (ROS)titanium dioxide nanoparticles (TiO2 NPs)

Identifiers

PMID34730869
PMCPMC9947743

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.