ArticleRheumatology (Oxford, England)2022
Hypothyroidism in vasculitis.
Article in Rheumatology (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Role of 18F-FDG PET/CT in assessing systemic involvement in ANCA-associated vasculitis.Clinical and experimental medicine · 2025Article
- Clinical associations with thyroid disease in ANCA-associated vasculitis.Clinical rheumatology · 2024Article
- Circulating Autoantibodies in Adults with Hashimoto's Thyroiditis: New Insights from a Single-Center, Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2024Article
- Article
- Analysis of Thyroid Function in ANCA-Associated Vasculitis Patients with Renal Injury.Journal of personalized medicine · 2024Article
- Histological Alterations in Hashimoto's Disease: A Case-Series Ultrastructural Study.Medicines (Basel, Switzerland) · 2023Article
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Authors and funding
16 authors at 12 institutions in 2 countries.
Funding
Abstract
objectiveTo study the prevalence, risk and clinical associations of hypothyroidism among several forms of vasculitis.
methodsPatients with GCA, Takayasu's arteritis (TAK), PAN and the three forms of ANCA-associated vasculitis [AAV; granulomatosis with polyangiitis (GPA), microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis (EGPA)] enrolled in a prospective, multicentre, longitudinal study were included.
resultsThe study included data on 2085 patients [63% female, 90% White] with a mean age of 54.6 years (s.d. 17.2). Diagnoses were GCA (20%), TAK (11%), PAN (5%), GPA (42%), microscopic polyangiitis (8%) and EGPA (14%). Hypothyroidism was present in 217 patients (10%) (83% female), with a mean age 59.8 years (s.d. 14.5). Age- and sex-adjusted risk of hypothyroidism was GCA, odds ratio (OR) 0.61 (95% CI 0.41, 0.90); TAK, OR 0.57 (95% CI 0.31, 1.03); PAN, OR 0.59 (95% CI 0.25, 1.38); GPA, OR 1.51 (95% CI 1.12, 2.05); microscopic polyangiitis, OR 1.81 (95% CI 1.18, 2.80) and EGPA, OR 0.82 (95% CI 0.52, 1.30). Among patients with AAV, age- and sex-adjusted risk of hypothyroidism was higher with positive MPO-ANCA [OR 1.89 (95% CI 1.39, 2.76)]. The clinical manifestations of vasculitis were similar in patients with and without hypothyroidism, except transient ischaemic attacks, which were more frequently observed in patients with GCA and hypothyroidism (12% vs 2%; P = 0.001).
conclusionsDifferences in the risk of hypothyroidism among vasculitides may be due to genetic susceptibilities or immune responses. This study confirms an association of hypothyroidism with MPO-ANCA.
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