ArticlePlant physiology2022
Unique features of mRNA m6A methylomes during expansion of tomato (Solanum lycopersicum) fruits.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 72 citations in OpenAlex.
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- Analysis of Non-Coding RNAs and N6-Methyladenosine-Modified Genes in Response to flg22 in Grape Immunity.Plant biotechnology journal · 2025Article
- Transcriptomic and epigenetic signatures of tomato fruit after postharvest UV-C irradiation are associated with the maintenance of fruit quality.Plant biotechnology journal · 2025Article
- The role of NTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
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- Subgenome Dominance in Allotetraploid Actinidia valvata Regulates RNA mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Epigenetics, flavor, and tomatoes: A love triangle based on a stable relationship.Plant physiology · 2025Article
- Genome-Wide Identification and Evolutionary Analysis of m6A-Related Gene Family in Poplar Nanlin895.Plants (Basel, Switzerland) · 2025Article
- Identification and expression analysis of NBMC genomics · 2025Article
- Identification and Functional Exploration of theInternational journal of molecular sciences · 2025Article
- RNA modifications in plant biotic interactions.Plant communications · 2025Review
- Crosstalk between RNA mPlant communications · 2024Review
- Ethylene in fruits: beyond ripening control.Horticulture research · 2024Article
- Recent Insights into the Physio-Biochemical and Molecular Mechanisms of Low Temperature Stress in Tomato.Plants (Basel, Switzerland) · 2024Review
- Article
- The mProceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic messenger RNA. Although the role of m6A has been demonstrated in many biological processes, including embryonic development, flowering time control, microspore generation, fruit ripening, and stress responses, its contribution to other aspects of plant development still needs to be explored. Herein, we show the potential link between m6A deposition and the expansion of tomato (Solanum lycopersicum) fruits through parallel m6A-immunoprecipitation-sequencing (m6A-seq) and RNA-seq analyses. We found that global m6A levels increased during tomato fruit expansion from immature green to mature green stage. m6A-seq revealed that thousands of protein-coding genes are m6A-modified mainly in the 3'-untranslated regions. m6A-seq and RNA-seq analyses showed a positive association between m6A methylation and mRNA abundance. In particular, a large number of fruit expansion-related genes involved in hormone responses and endoreduplication were m6A modified and expressed more actively than the non-m6A-modified genes, suggesting a potential role of m6A modification in tomato fruit expansion. Importantly, altering m6A levels by direct injection of 3-deazaneplanocin A (DA; m6A writer inhibitor) or meclofenamic acid (MA; m6A eraser inhibitor) into tomato fruits suppressed fruit expansion; however, injection of exogenous DA or MA accelerated or delayed fruit ripening, respectively. Collectively, these results suggest a dynamic role of m6A methylation in the expansion and ripening of tomato fruits.
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