ArticlePlant physiology2022
A cluster of atypical resistance genes in soybean confers broad-spectrum antiviral activity.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- An atypical EF-hand domain containing resistance protein SRC4 boosts plant immunity in a calcium-enhanced manner.The Plant journal : for cell and molecular biology · 2026Article
- Systematic Screening of Host Interactors forPlants (Basel, Switzerland) · 2026Article
- Soybean transcription factors GmHSF-01 and GmNF-YC03 regulate the GmSRC7BMC plant biology · 2026Article
- Calcium signaling in soybean-virus interactions: emerging roles of calcium sensors in antiviral and environmental stress responses.Frontiers in plant science · 2026Review
- Identification of MicroRNAs Involved in Different Layers of Rice-Magnaporthe oryzae Interaction.Rice (New York, N.Y.) · 2025Article
- High Basal Expression and Dual Stress Responsiveness of Soybean (Plants (Basel, Switzerland) · 2025Article
- A comprehensive review of soybean RNL and TIR domain proteins.Plant molecular biology · 2024Review
- Pathogenicity, Host Resistance, and Genetic Diversity ofJournal of fungi (Basel, Switzerland) · 2024Article
- Development of an NLR-ID Toolkit and Identification of Novel Disease-Resistance Genes in Soybean.Plants (Basel, Switzerland) · 2024Article
- Genome-wide association study and haplotype analysis reveal novel candidate genes for resistance to powdery mildew in soybean.Frontiers in plant science · 2024Article
- Comprehensive analysis of soybean cultivars' response to SMV infection: genotypic association, molecular characterization, and defense gene expressions.Journal, genetic engineering & biotechnology · 2023Article
- Plant immunity in soybean: progress, strategies, and perspectives.Molecular breeding : new strategies in plant improvement · 2023Article
- Evolution patterns of NBS genes in the genus Dendrobium and NBS-LRR gene expression in D. officinale by salicylic acid treatment.BMC plant biology · 2022Article
- Cool (soy)beans! SMV RESISTANCE CLUSTER7 protects plants against viruses.Plant physiology · 2022Article
- Genome-wide identification and analysis of theFrontiers in genetics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Soybean mosaic virus (SMV) is a severe soybean (Glycine max) pathogen. Here we characterize a soybean SMV resistance cluster (SRC) that comprises five resistance (R) genes. SRC1 encodes a Toll/interleukin-1 receptor and nucleotide-binding site (TIR-NBS [TN]) protein, SRC4 and SRC6 encode TIR proteins with a short EF-hand domain, while SRC7 and SRC8 encode TNX proteins with a noncanonical basic secretory protein (BSP) domain at their C-termini. We mainly studied SRC7, which contains a noncanonical BSP domain and gave full resistance to SMV. SRC7 possessed broad-spectrum antiviral activity toward several plant viruses including SMV, plum pox virus, potato virus Y, and tobacco mosaic virus. The TIR domain alone was both necessary and sufficient for SRC7 immune signaling, while the NBS domain enhanced its activity. Nuclear oligomerization via the interactions of both TIR and NBS domains was essential for SRC7 function. SRC7 expression was transcriptionally inducible by SMV infection and salicylic acid (SA) treatment, and SA was required for SRC7 triggered virus resistance. SRC7 expression was posttranscriptionally regulated by miR1510a and miR2109, and the SRC7-miR1510a/miR2109 regulatory network appeared to contribute to SMV-soybean interactions in both resistant and susceptible soybean cultivars. In summary, we report a soybean R gene cluster centered by SRC7 that is regulated at both transcriptional and posttranscriptional levels, possesses a yet uncharacterized BSP domain, and has broad-spectrum antiviral activities. The SRC cluster is special as it harbors several functional R genes encoding atypical TIR-NBS-LRR (TNL) type R proteins, highlighting its importance in SMV-soybean interaction and plant immunity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.