Evidence map›Paper›PMID 34730514›Full record

ArticleeLife2021

Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1.

Stijn van Dorp, Ruoyi Qiu, Ucheor B Choi, Minnie M Wu, Michelle Yen, Michael Kirmiz, Axel T Brunger, Richard S Lewis

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Listening to the quiescence of single STIM1 dimers.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. Multiple weak brakes act in concert to control STIM1 and store-operated calcium entry.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Review
  12. A biased allosteric modulator functions as a molecular glue to induce βbioRxiv : the preprint server for biology · 2025
    Article
  13. STIM1 transmembrane helix dimerization captured by AI-guided transition path sampling.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Review
  15. Article
  16. Article
  17. Essential role of N-terminal SAM regions in STIM1 multimerization and function.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Review
  19. Single-Molecule FRET Analyses of NMDA Receptors.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Stijn van DorpDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States.ORCID 0000-0002-9940-7163
Ruoyi QiuDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States.
Ucheor B ChoiDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States.ORCID 0000-0003-1541-2967
Minnie M WuDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States.
Michelle YenDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States.
Michael KirmizDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States.
Axel T BrungerDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States.ORCID 0000-0001-5121-2036
Richard S LewisDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States.ORCID 0000-0002-6010-7403
Stanford University · USHoward Hughes Medical Institute · US

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Vittorio Sebastiano · 2007 to 2026
$71.4M
Ion Channels and Signaling Mechanisms in T LymphocytesR37GM045374 · NIGMS · STANFORD UNIVERSITY · PI LEWIS, RICHARD S · 2012 to 2021
$6.2M
Single molecule studies of SNARE-induced vesicle fusionR37MH063105 · NIMH · STANFORD UNIVERSITY · PI BRUNGER, AXEL T · 2011 to 2020
$4.7M
NCI NIH HHS P30 CA124435NIGMS NIH HHS R37 GM045374NIMH NIH HHS R37 MH063105
6 · The paper itself

Abstract

The dimeric ER Ca

Indexed as

Calcium SignalingCell MembraneEndoplasmic ReticulumFluorescence Resonance Energy TransferNeoplasm ProteinsORAI1 ProteinStromal Interaction Molecule 1Neoplasm ProteinsORAI1 ProteinORAI1 protein, humanSTIM1 protein, humanStromal Interaction Molecule 1calcium signalinghumanmolecular biophysicssmFRETSTIM1store-operated calcium entrystructural biology

Identifiers

PMID34730514
PMCPMC8651296
OpenAlexW3209942654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.