Evidence map›Paper›PMID 34730513›Full record

ArticleeLife2021

Proximity labeling identifies LOTUS domain proteins that promote the formation of perinuclear germ granules in

Ian F Price, Hannah L Hertz, Benjamin Pastore, Jillian Wagner, Wen Tang

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. LOTUS-domain proteins activate Vasa to drive germ granule assembly.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Kinetochore components are perinuclear and form condensates inbioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. How germ granules promote germ cell fate.Nature reviews. Genetics · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ian F PriceDepartment of Biological Chemistry and Pharmacology, Columbus, United States.ORCID 0000-0002-7820-8958
Hannah L HertzDepartment of Biological Chemistry and Pharmacology, Columbus, United States.
Benjamin PastoreDepartment of Biological Chemistry and Pharmacology, Columbus, United States.
Jillian WagnerDepartment of Biological Chemistry and Pharmacology, Columbus, United States.
Wen TangDepartment of Biological Chemistry and Pharmacology, Columbus, United States.ORCID 0000-0001-6684-5258
State Library of Ohio · USThe Ohio State University · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Heritable macromolecules in C. elegans germ granulesR35GM142580 · NIGMS · OHIO STATE UNIVERSITY · PI TANG, WEN · 2021 to 2025
$2.0M
Ohio State University Neuroscience Center Core-Core EP30NS104177 · NINDS · OHIO STATE UNIVERSITY · PI ASKWITH, CANDICE C · 2017 to 2020
$1.9M
Biogenesis of piRNA and its function in endogenous gene regulationR00GM124460 · NIGMS · OHIO STATE UNIVERSITY · PI TANG, WEN · 2019 to 2021
$747k
A spinning disk confocal microscope for live-cell imagingS10OD010383 · OD · OHIO STATE UNIVERSITY · PI BROWN, ANTHONY · 2012 to 2012
$600k
Acquisition of a Next Generation Orbitrap MSS10OD018056 · OD · OHIO STATE UNIVERSITY · PI FREITAS, MICHAEL A. · 2014 to 2014
$573k
Zeiss LSM 800 confocal microscope with AiryscanS10OD026842 · OD · OHIO STATE UNIVERSITY · PI BROWN, ANTHONY · 2019 to 2019
$369k
Biogenesis of piRNA and its function in endogenous gene regulationK99GM124460 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI TANG, WEN · 2017 to 2018
$180k
NIGMS NIH HHS K99 GM124460NIGMS NIH HHS R00 GM124460NIGMS NIH HHS R35 GM142580NIH HHS P40 OD010440NIH HHS S10 OD010383NIH HHS S10 OD018056NIH HHS S10 OD026842NINDS NIH HHS P30 NS104177
6 · The paper itself

Abstract

The germ line produces gametes that transmit genetic and epigenetic information to the next generation. Maintenance of germ cells and development of gametes require germ granules-well-conserved membraneless and RNA-rich organelles. The composition of germ granules is elusive owing to their dynamic nature and their exclusive expression in the germ line. Using

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsClustered Regularly Interspaced Short Palindromic RepeatsGene EditingGerm Cell Ribonucleoprotein GranulesGerm CellsProtein DomainsRNA InterferenceCaenorhabditis elegans ProteinsC. eleganscell biologygerm granulesLOTUS domain proteinp granulesproximity labelingvasa proteins

Identifiers

PMID34730513
PMCPMC8616582
OpenAlexW3209724953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.