Evidence map›Paper›PMID 34730410›Full record

ArticleMicrobiology spectrum2021

Bacterial Epidemiology and Antimicrobial Resistance Profiles in Children Reported by the ISPED Program in China, 2016 to 2020.

Pan Fu, Hongmei Xu, Chunmei Jing, Jikui Deng, Hongmei Wang, Chunzhen Hua, Yinghu Chen, Xuejun Chen, Ting Zhang, Hong Zhang and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  11. Multidrug-ResistantVeterinary medicine international · 2026
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Pan FuDepartment of Clinical Microbiology Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.ORCID 0000-0003-2587-4348
Hongmei XuInfectious Disease Department, Children's Hospital of Chonqing Medical University, Chongqing, China.
Chunmei JingDepartment of Medical Laboratory, Children's Hospital of Chonqing Medical University, Chongqing, China.
Jikui DengInfectious Disease Department, Shenzhen Children's Hospital, Shenzhen, China.
Hongmei WangInfectious Disease Department, Shenzhen Children's Hospital, Shenzhen, China.
Chunzhen HuaInfectious Disease Department, Children's Hospital of Zhejiang University, Zhejiang, China.
Yinghu ChenInfectious Disease Department, Children's Hospital of Zhejiang University, Zhejiang, China.
Xuejun ChenDepartment of Medical Laboratory, Children's Hospital of Zhejiang University, Zhenjiang, China.
Ting ZhangDigestive and Infectious Disease Department, Children's Hospital of Shanghai Jiaotong University, Shanghai, China.
Hong ZhangDepartment of Medical Laboratory, Children's Hospital of Shanghai Jiaotong University, Shanghai, China.
Yiping ChenPediatric Infectious Disease Department, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Jinhong YangDepartment of Medical Laboratory, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Aiwei LinInfectious Disease Department, Qilu Children's Hospital of Shandong University, Shandong, China.
Shifu WangDepartment of Medical Laboratory, Qilu Children's Hospital of Shandong University, Shandong, China.
Qing CaoInfectious Disease Department, Shanghai Children's Medical Center, Shanghai, China.
Xing WangDepartment of Medical Laboratory, Shanghai Children's Medical Center, Shanghai, China.
Huiling DengInfectious Disease Department, Xi'an Children's Hospital, Xi'an, China.
Sancheng CaoDepartment of Medical Laboratory, Xi'an Children's Hospital, Xi'an, China.
Jianhua HaoInfectious Disease Department, Children's Hospital of Kaifeng City, Kaifeng, China.
Wei GaoDepartment of Medical Laboratory, Children's Hospital of Kaifeng City, Kaifeng, China.
Yuanyuan HuangPediatric Department, First Hospital Affiliated to Jilin University, Changchun, China.
Hui YuInfectious Disease Department, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.ORCID 0000-0003-1342-5537
Chuanqing WangDepartment of Clinical Microbiology Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.ORCID 0000-0002-0158-9094

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Infectious Disease Surveillance of Pediatrics (ISPED) program was established in 2015 to monitor and analyze the trends of bacterial epidemiology and antimicrobial resistance (AMR) in children. Clinical bacterial isolates were collected from 11 tertiary care children's hospitals in China in 2016 to 2020. Antimicrobial susceptibility testing was carried out using the Kirby-Bauer method or automated systems, with interpretation according to the Clinical and Laboratory Standards Institute 2019 breakpoints. A total of 288,377 isolates were collected, and the top 10 predominant bacteria were Escherichia coli, Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Streptococcus pyogenes, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Acinetobacter baumannii. In 2020, the coronavirus disease 2019 (COVID-19) pandemic year, we observed a significant reduction in the proportion of respiratory tract samples (from 56.9% to 44.0%). A comparable reduction was also seen in the primary bacteria mainly isolated from respiratory tract samples, including S. pneumoniae, H. influenzae, and S. pyogenes. Multidrug-resistant organisms (MDROs) in children were commonly observed and presented higher rates of drug resistance than sensitive strains. The proportions of carbapenem-resistant K. pneumoniae (CRKP), carbapenem-resistant A. baumannii (CRAB), carbapenem-resistant P. aeruginosa (CRPA), and methicillin-resistant S. aureus (MRSA) strains were 19.7%, 46.4%%, 12.8%, and 35.0%, respectively. The proportions of CRKP, CRAB, and CRPA strains all showed decreasing trends between 2015 and 2020. Carbapenem-resistant

Indexed as

Drug Resistance, BacterialAcinetobacter baumanniiAnti-Bacterial AgentsBacteriaChildChinaCommunicable DiseasesCOVID-19Escherichia coliHumansKlebsiella pneumoniaeMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMoraxella catarrhalisPseudomonas aeruginosaSARS-CoV-2Anti-Bacterial Agentsantimicrobial resistancebacteriachildrenInfectious Disease Surveillance of Pediatrics (ISPED)multidrug-resistant organisms

Identifiers

PMID34730410
PMCPMC8567242

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.