SynthesisArthritis & rheumatology (Hoboken, N.J.)2022
Recreational Physical Activity and Risk of Incident Knee Osteoarthritis: An International Meta-Analysis of Individual Participant-Level Data.
Synthesis in Arthritis & rheumatology (Hoboken, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Association between physical activity and knee osteoarthritis: a comprehensive systematic review and meta-analysis.Journal of global health · 2025Pooled it
- Impact of Running on the Risk and Progression of Knee Osteoarthritis: A Review of Current Evidence.Cureus · 2026Review
- Physical activity and joint health: Implications for knee osteoarthritis disease pathophysiology and mechanics.Experimental physiology · 2026Review
- Dose-response associations between accelerometer-derived physical activity and sedentary behaviour and hip/knee osteoarthritis: a prospective cohort study.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026Article
- More time spent in moderate-to-vigorous physical activity and sleep is associated with a lower incidence of hip or knee osteoarthritis.BMJ open sport & exercise medicine · 2026Article
- Letter to the Editor on "Is physical activity in polluted environments beneficial or detrimental to osteoporosis and osteoarthritis? - A prospective cohort study".International journal of surgery (London, England) · 2026Article
- Correlation between Kellgren-Lawrence classification of osteoarthritis and Knee Injury and Osteoarthritis Outcome Score.World journal of orthopedics · 2025Article
- Association of activity with the risk of developing musculoskeletal pain in the All of Us research program.The journal of pain · 2025Article
- Associations of physical activity with the risks of osteoarthritis and subtypes : a population-based cohort study of UK Biobank data.Bone & joint research · 2025Article
- Revealing the mediating mechanisms between BMI and osteoarthritis: a Mendelian randomization and mediation analysis.Aging clinical and experimental research · 2025Article
- Association of Physical Function, Quantity, and Quality of the Quadriceps with Postoperative Physical Activity Before Total Knee Arthroplasty.Journal of clinical medicine · 2025Article
- Genetic causal relationship between physical activity and osteoarthritis: a two-sample Mendelian randomization study.Archives of medical science : AMS · 2025Article
- Comparative study on the association between types of physical activity, physical activity levels, and the incidence of osteoarthritis in adults: the NHANES 2007-2020.Scientific reports · 2024Article
- Causal factors for osteoarthritis risk revealed by mendelian randomization analysis.Aging clinical and experimental research · 2024Review
- Association of physical activity trajectories over 8 years and risk of knee replacement: data from the osteoarthritis initiative.BMC musculoskeletal disorders · 2024Article
- Weight-Bearing Physical Activity, Lower-Limb Muscle Mass, and Risk of Knee Osteoarthritis.JAMA network open · 2024Article
- Investigating the causal relationship between physical activity and incident knee osteoarthritis: a two-sample Mendelian randomization study.Scientific reports · 2024Article
- Causal effect of physical activity and sedentary behaviors on the risk of osteoarthritis: a univariate and multivariate Mendelian randomization study.Scientific reports · 2023Article
- Assessment of causal effects of physical activity on the risk of osteoarthritis: a two-sample Mendelian randomization study.BMC medical genomics · 2023Article
- Relationships between the Physical Activity Intensity and the Medical Expenditure of Middle-Aged and Elderly People: Parsing from the CHARLS Database.Behavioral sciences (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 8 institutions in 3 countries.
Funding
Abstract
objectiveThe effect of physical activity on the risk of developing knee osteoarthritis (OA) is unclear. We undertook this study to examine the relationship between recreational physical activity and incident knee OA outcomes using comparable physical activity and OA definitions.
methodsData were acquired from 6 global, community-based cohorts of participants with and those without knee OA. Eligible participants had no evidence of knee OA or rheumatoid arthritis at baseline. Participants were followed up for 5-12 years for incident outcomes including the following: 1) radiographic knee OA (Kellgren-Lawrence [K/L] grade ≥2), 2) painful radiographic knee OA (radiographic OA with knee pain), and 3) OA-related knee pain. Self-reported recreational physical activity included sports and walking/cycling activities and was quantified at baseline as metabolic equivalents of task (METs) in days per week. Risk ratios (RRs) were calculated and pooled using individual participant data meta-analysis. Secondary analysis assessed the association between physical activity, defined as time (hours per week) spent in recreational physical activity and incident knee OA outcomes.
resultsBased on a total of 5,065 participants, pooled RR estimates for the association of MET days per week with painful radiographic OA (RR 1.02 [95% confidence interval (95% CI) 0.93-1.12]), radiographic OA (RR 1.00 [95% CI 0.94-1.07]), and OA-related knee pain (RR 1.00 [95% CI 0.96-1.04]) were not significant. Similarly, the analysis of hours per week spent in physical activity also showed no significant associations with all outcomes.
conclusionOur findings suggest that whole-body, physiologic energy expenditure during recreational activities and time spent in physical activity were not associated with incident knee OA outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.