Evidence map›Paper›PMID 34730185›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2022

Intra-Areal Visual Topography in Primate Brains Mapped with Probabilistic Tractography of Diffusion-Weighted Imaging.

K Tang-Wright, J E T Smith, H Bridge, K L Miller, T B Dyrby, B Ahmed, N L Reislev, J Sallet, A J Parker, K Krug

Open access · hybridAbstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 5 countries.

K Tang-WrightDepartment of Physiology Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
J E T SmithDepartment of Physiology Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
H BridgeWellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
K L MillerWellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
T B DyrbyDanish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Amager & Hvidovre, 2650 Hvidovre, Denmark.
B AhmedDepartment of Physiology Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
N L ReislevDanish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Amager & Hvidovre, 2650 Hvidovre, Denmark.
J SalletWellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, UK.ORCID 0000-0002-7878-0209
A J ParkerDepartment of Physiology Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.ORCID 0000-0001-5800-0407
K KrugDepartment of Physiology Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.ORCID 0000-0001-7119-9350
Centre for Human Genetics · GBHvidovre Hospital · DKUniversity of Oxford · GBUniversité Claude Bernard Lyon 1 · FR

Funding

Biotechnology and Biological Sciences Research Council BB/H016902/1Medical Research Council MR/K014382/1Medical Research Council MR/K02213X/1Medical Research Council MR/V034723/1Wellcome TrustWellcome Trust 101092/Z/13/ZWellcome Trust 105651/Z/14/ZWellcome Trust 203139/Z/16/Z
6 · The paper itself

Abstract

Noninvasive diffusion-weighted magnetic resonance imaging (dMRI) can be used to map the neural connectivity between distinct areas in the intact brain, but the standard resolution achieved fundamentally limits the sensitivity of such maps. We investigated the sensitivity and specificity of high-resolution postmortem dMRI and probabilistic tractography in rhesus macaque brains to produce retinotopic maps of the lateral geniculate nucleus (LGN) and extrastriate cortical visual area V5/MT based on their topographic connections with the previously established functional retinotopic map of primary visual cortex (V1). We also replicated the differential connectivity of magnocellular and parvocellular LGN compartments with V1 across visual field positions. Predicted topographic maps based on dMRI data largely matched the established retinotopy of both LGN and V5/MT. Furthermore, tractography based on in vivo dMRI data from the same macaque brains acquired at standard field strength (3T) yielded comparable topographic maps in many cases. We conclude that tractography based on dMRI is sensitive enough to reveal the intrinsic organization of ordered connections between topographically organized neural structures and their resultant functional organization.

Indexed as

Visual CortexVisual PathwaysAnimalsDiffusion Magnetic Resonance ImagingGeniculate BodiesMacaca mulattaLGNmacaquepathwaysretinotopyvisual cortex

Identifiers

PMID34730185
PMCPMC9201591
OpenAlexW3209842688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.