Evidence map›Paper›PMID 34730081›Full record

ArticleCNS spectrums2023

Neurobiology of subtypes of trichotillomania and skin picking disorder.

Jon E Grant, Richard A I Bethlehem, Samuel R Chamberlain, Tara S Peris, Emily J Ricketts, Joseph O'Neill, Darin D Dougherty, Dan Stein, Christine Lochner, Douglas W Woods and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS spectrums, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Psychodermatology: Current Scope and Future Prospects.Indian dermatology online journal · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jon E GrantDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0001-7784-7021
Richard A I BethlehemDepartment of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
Samuel R ChamberlainDepartment of Psychiatry, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Tara S PerisDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA.
Emily J RickettsDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA.
Joseph O'NeillDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA.
Darin D DoughertyDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Dan SteinDepartment of Psychiatry, University of Cape Town, Cape Town, South Africa.
Christine LochnerDepartment of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
Douglas W WoodsDepartment of Psychology, Marquette University, Milwaukee, Wisconsin, USA.
John PiacentiniDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA.
Nancy J KeuthenDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Funding

Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
NCATS NIH HHS UL1 TR000430Wellcome Trust 110049
6 · The paper itself

Abstract

backgroundTrichotillomania (TTM) and skin picking disorder (SPD) are common and often debilitating mental health conditions, grouped under the umbrella term of body-focused repetitive behaviors (BFRBs). Recent clinical subtyping found that there were three distinct subtypes of TTM and two of SPD. Whether these clinical subtypes map on to any unique neurobiological underpinnings, however, remains unknown.

methodsTwo hundred and fifty one adults [193 with a BFRB (85.5% [n = 165] female) and 58 healthy controls (77.6% [n = 45] female)] were recruited from the community for a multicenter between-group comparison using structural neuroimaging. Differences in whole brain structure were compared across the subtypes of BFRBs, controlling for age, sex, scanning site, and intracranial volume.

resultsWhen the subtypes of TTM were compared, low awareness hair pullers demonstrated increased cortical volume in the lateral occipital lobe relative to controls and sensory sensitive pullers. In addition, impulsive/perfectionist hair pullers showed relative decreased volume near the lingual gyrus of the inferior occipital-parietal lobe compared with controls.

conclusionsThese data indicate that the anatomical substrates of particular forms of BFRBs are dissociable, which may have implications for understanding clinical presentations and treatment response.

Indexed as

TrichotillomaniaAdultBrainComorbidityFemaleHumansImpulsive Behaviorimagingneurobiologyskin picking disordersubtypesTrichotillomania

Identifiers

PMID34730081
PMCPMC7614223

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.