Evidence map›Paper›PMID 34729992›Full record

ArticleJournal of the American Heart Association2021

Coronary Endothelium-Dependent Vasomotor Function After Drug-Eluting Stent and Bioresorbable Scaffold Implantation.

Josep Gomez-Lara, Loreto Oyarzabal, Luis Ortega-Paz, Salvatore Brugaletta, Rafael Romaguera, Neus Salvatella, Gerard Roura, Fernando Rivero, Lara Fuentes, Fernando Alfonso and 6 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06448637 (DRUG RELEASING BALL vs. PHARMACOACTIVE STENT IN LARGE VESSELS), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06448637 narecruitingnot on this mapstarted 2024, after this paper: background citation

DRUG RELEASING BALL vs. PHARMACOACTIVE STENT IN LARGE VESSELS: MORPHOLOGICAL ANALYSIS AND FUNCTION VASOMOTOR (DEBORA STUDY)

TypeinterventionalSponsorFundación EPICRan2024 to 2027Enrolled94ConditionsCoronary Artery DiseaseArmsDrug Coated Balloon (DCB), Drug Eluting Stent (DES)
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Josep Gomez-LaraUniversity Hospital of Bellvitge, Biomedical Research Institute of Bellvitge (IDIBELL) University of Barcelona, L' Hospitalet de Llobregat Spain.ORCID 0000-0001-9731-4767
Loreto OyarzabalUniversity Hospital of Bellvitge, Biomedical Research Institute of Bellvitge (IDIBELL) University of Barcelona, L' Hospitalet de Llobregat Spain.ORCID 0000-0002-4090-6646
Luis Ortega-PazClinic Hospital of Barcelona August Pi i Sunyer Biomedical Research Institute (IDIBAPS) Barcelona Spain.ORCID 0000-0002-9567-3253
Salvatore BrugalettaClinic Hospital of Barcelona August Pi i Sunyer Biomedical Research Institute (IDIBAPS) Barcelona Spain.ORCID 0000-0001-5845-1435
Rafael RomagueraUniversity Hospital of Bellvitge, Biomedical Research Institute of Bellvitge (IDIBELL) University of Barcelona, L' Hospitalet de Llobregat Spain.ORCID 0000-0002-6413-3502
Neus SalvatellaHeart Disease Research Group Mar Hospital, Biomedical Research Institute of Mar Hospital (IMIM) Barcelona Spain.
Gerard RouraUniversity Hospital of Bellvitge, Biomedical Research Institute of Bellvitge (IDIBELL) University of Barcelona, L' Hospitalet de Llobregat Spain.
Fernando RiveroUniversity Hospital of La Princesa Health Resaerch Institute of La Princesa; CIBER-CV Madrid Spain.ORCID 0000-0002-3676-0277
Lara FuentesUniversity Hospital of Bellvitge, Biomedical Research Institute of Bellvitge (IDIBELL) University of Barcelona, L' Hospitalet de Llobregat Spain.
Fernando AlfonsoUniversity Hospital of La Princesa Health Resaerch Institute of La Princesa; CIBER-CV Madrid Spain.ORCID 0000-0002-7480-2511
Imanol OtaeguiInterventional Cardiology Department University Hospital of Vall Hebron Barcelona Spain.
Bert VandelooUniversity Hospital of Bellvitge, Biomedical Research Institute of Bellvitge (IDIBELL) University of Barcelona, L' Hospitalet de Llobregat Spain.ORCID 0000-0003-1152-9594
Beatriz VaquerizoHeart Disease Research Group Mar Hospital, Biomedical Research Institute of Mar Hospital (IMIM) Barcelona Spain.
Manel SabateClinic Hospital of Barcelona August Pi i Sunyer Biomedical Research Institute (IDIBAPS) Barcelona Spain.ORCID 0000-0002-2316-3705
Josep Comin-ColetUniversity Hospital of Bellvitge, Biomedical Research Institute of Bellvitge (IDIBELL) University of Barcelona, L' Hospitalet de Llobregat Spain.ORCID 0000-0001-8780-720X
Joan-Antoni Gomez-HospitalUniversity Hospital of Bellvitge, Biomedical Research Institute of Bellvitge (IDIBELL) University of Barcelona, L' Hospitalet de Llobregat Spain.ORCID 0000-0002-3249-3095
Bellvitge University Hospital · ESConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESHospital Del Mar · ESHospital Universitario de La Princesa · ESVall d'Hebron Hospital Universitari · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Early generation drug-eluting stents (DESs) showed a high grade of coronary endothelial dysfunction that was attributed to lack of stent reendothelialization. Endothelium-dependent vasomotor response of current DESs and bioresorbable scaffolds (BRSs) remains unknown. This study sought to assess the device-related endothelial function of current devices and to correlate neointima healing with endothelial function. Methods and Results A total of 206 patients from 4 randomized trials treated with the durable-polymer everolimus-eluting Xience (n=44), bioresorbable-polymer sirolimus-eluting Orsiro (n=35), polymer-free biolimus-eluting Biofreedom (n=24), bioactive endothelial-progenitor cell-capturing sirolimus-eluting Combo DES (n=25), polymer-based everolimus-eluting Absorb (n=44), and Mg-based sirolimus-eluting Magmaris BRS (n=34) underwent endothelium-dependent vasomotor tests and optical coherence tomography imaging, as per protocol, at follow-up. Crude vasomotor responses of distal segments to low-dose acetylcholine (10

Indexed as

Drug-Eluting StentsPercutaneous Coronary InterventionAbsorbable ImplantsAcetylcholineCoronary AngiographyEndotheliumEverolimusHumansNeointimaPolymersProsthesis DesignSirolimusTreatment OutcomeAcetylcholineEverolimusPolymersSirolimusdrug‐eluting stentsendothelial dysfunctionoptical coherence tomographyST‐segment–elevation myocardial infarction

Identifiers

PMID34729992
PMCPMC8751934
OpenAlexW3208402070

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.