Evidence map›Paper›PMID 34729990›Full record

ArticleJournal of the American Heart Association2021

Enhanced Thrombotic Responses Are Associated With Striatin Deficiency and Aldosterone.

Anna Gromotowicz-Poplawska, Robert Flaumenhaft, Shadi K Gholami, Glenn Merrill-Skoloff, Ewa Chabielska, Gordon H Williams, Jose R Romero

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Recent progress in unraveling cardiovascular complications associated with primary aldosteronism: a succinct review.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Review
  5. Article
  6. The Effect of Aldosterone on Cardiorenal and Metabolic Systems.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Anna Gromotowicz-PoplawskaDivision of Endocrinology, Diabetes, and Hypertension Department of Medicine Brigham and Women's Hospital Boston MA.ORCID 0000-0001-6742-3356
Robert FlaumenhaftDivision of Hemostasis and Thrombosis Beth Israel Deaconess Medical Center Boston MA.
Shadi K GholamiDivision of Endocrinology, Diabetes, and Hypertension Department of Medicine Brigham and Women's Hospital Boston MA.ORCID 0000-0003-1429-118X
Glenn Merrill-SkoloffDivision of Hemostasis and Thrombosis Beth Israel Deaconess Medical Center Boston MA.ORCID 0000-0003-2337-5107
Ewa ChabielskaDepartment of Biopharmacy Medical University of Bialystok Bialystok Poland.
Gordon H WilliamsDivision of Endocrinology, Diabetes, and Hypertension Department of Medicine Brigham and Women's Hospital Boston MA.
Jose R RomeroDivision of Endocrinology, Diabetes, and Hypertension Department of Medicine Brigham and Women's Hospital Boston MA.ORCID 0000-0001-8225-0772
Brigham and Women's Hospital · USBeth Israel Deaconess Medical Center · USMedical University of Białystok · PL

Funding

Thiol Isomerases in Hemostasis and ThrombosisR35HL135775 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FLAUMENHAFT, ROBERT C · 2017 to 2023
$5.5M
Striatin, Aldosterone and HypertensionR01HL114765 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GARZA, AMANDA ELIZABETH, WILLIAMS, GORDON H · 2013 to 2017
$4.3M
Targeting the Endothelium in SepsisR01HL125275 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FLAUMENHAFT, ROBERT C, PARIKH, SAMIR M · 2014 to 2018
$4.2M
Salt Sensitive Hypertension and StriatinR01HL144779 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WILLIAMS, GORDON H · 2019 to 2022
$3.3M
NHLBI NIH HHS R01 HL125275NHLBI NIH HHS R01 HL144779NHLBI NIH HHS R35 HL135775
6 · The paper itself

Abstract

Background In addition to its role on blood pressure, aldosterone (ALDO) also affects the hemostatic system leading to increased experimental thrombosis. Striatin is an intermediate in the rapid, nongenomic actions of ALDO. Striatin heterozygote knockout (

Indexed as

HypertensionThrombosisAldosteroneAnimalsCalmodulin-Binding ProteinsFibrinMembrane ProteinsMiceNerve Tissue ProteinsRandom AllocationSodium Chloride, DietaryTranscription FactorsAldosteroneCalmodulin-Binding ProteinsFibrinMembrane ProteinsNerve Tissue ProteinsSodium Chloride, DietaryStrn protein, mouseTranscription Factorsaldosteronefibrinplateletstriatinthrombosis

Identifiers

PMID34729990
PMCPMC8751928
OpenAlexW3210122016

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.