Evidence map›Paper›PMID 34729946›Full record

ArticleCancer reports (Hoboken, N.J.)2022

Does previous history of cancer or atypia predict histologic upgrade for pure intraductal papillomas diagnosed via core biopsy? A study of 490 cases at a single institution.

J Jaime Alberty-Oller, Sylvia Reyes, Erin Moshier, Meng Ru, Sarah Weltz, Antonio Santos, Kereeti Pisapati, Elisa Port, Shabnam Jaffer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer reports (Hoboken, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

J Jaime Alberty-OllerMount Sinai Hospital, Dubin Breast Center of the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0003-3125-6474
Sylvia ReyesMount Sinai Hospital, Dubin Breast Center of the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Erin MoshierMount Sinai Hospital, Dubin Breast Center of the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Meng RuMount Sinai Hospital, Dubin Breast Center of the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Sarah WeltzMount Sinai Hospital, Dubin Breast Center of the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Antonio SantosMount Sinai Hospital, Dubin Breast Center of the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Kereeti PisapatiMount Sinai Hospital, Dubin Breast Center of the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Elisa PortMount Sinai Hospital, Dubin Breast Center of the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Shabnam JafferMount Sinai Hospital, Dubin Breast Center of the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-9843-7427
Mount Sinai Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundManagement of pure intraductal papillomas (IDP) without atypia diagnosed on core needle biopsy (CNB) remains controversial given highly variable rates of upgrade in the literature.

aimWe sought to identify clinical and histologic factors that predict upgrade to atypia or malignancy in a large population. METHODS AND

resultsA retrospective review was performed of all cases of pure IDP diagnosed on CNB and then surgically excised at a single institution from 2008 to 2018. Clinical, radiologic, and pathologic factors were compared in the no upgrade, upgrade to atypia, or upgrade to cancer groups. Univariate analysis was performed comparing no upgrade and upgrade to cancer or atypia. Four hundred and thirty nine patients were identified with a total of 490 IDP and a median age of 50 years (range 16-85). Of these patients, 54 (12.3%) were upgraded to atypia after surgical excision and five (1.1%) were upgraded to cancer. The presence of multiple papillomas in a single patient was a significant predictor of upgrade to cancer or atypia (p < .01), as well as age over ≥55 years (p < .01) and a prior history of cancer (p < .01). No other clinical, radiologic and histologic factors were found to be significant predictors of upgrade. 40/439 (9.1%) patients in the total cohort had prior history of cancer, and of these, 2/40 (5%) were found to have a new cancer after excision.

conclusionsIn patients with pure IDP on CNB, the upgrade rate to malignancy was 1.1%, while 12.3% were upgraded to atypia. The clinical significance of identifying atypia in a papilloma is unknown, especially in a patient with a prior history of atypia or cancer. However, the majority of patients who were upgraded to either atypia or cancer had no prior history of high-risk or malignant breast disease and are therefore considered true clinical upgrades. As such excision for IDP should be considered.

Indexed as

Breast NeoplasmsPapillomaPapilloma, IntraductalAdolescentAdultAgedAged, 80 and overBiopsy, Large-Core NeedleFemaleHumansMiddle AgedYoung Adultbreast cancercore biopsyintraductal papilloma

Identifiers

PMID34729946
PMCPMC8955065
OpenAlexW3209133428

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.