Evidence map›Paper›PMID 34729838›Full record

ArticleNMR in biomedicine2022

Improving hyperpolarized

Abdullah S Bdaiwi, Peter J Niedbalski, Md M Hossain, Matthew M Willmering, Laura L Walkup, Hui Wang, Robert P Thomen, Kai Ruppert, Jason C Woods, Zackary I Cleveland

Open access · greenAbstract read
In one paragraph

Article in NMR in biomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Functional Pulmonary Imaging.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  3. Magnetic resonance in medicine · 2025
    Article
  4. A thermally polarized, dissolved-phaseJournal of magnetic resonance (San Diego, Calif. : 1997) · 2025
    Article
  5. UltrasensitiveAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  6. Article
  7. Quantifying abnormal alveolar microstructure in cystic fibrosis lung disease via hyperpolarizedJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2024
    Article
  8. Analytical corrections for BMagnetic resonance in medicine · 2024
    Article
  9. BMagnetic resonance in medicine · 2023
    Article
  10. Diffusion weighted hyperpolarizedMagnetic resonance in medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Abdullah S BdaiwiCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0001-7835-7032
Peter J NiedbalskiCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Md M HossainDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Matthew M WillmeringCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Laura L WalkupCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Hui WangPhilips Healthcare, Cincinnati, Ohio, USA.
Robert P ThomenCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Kai RuppertCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Jason C WoodsCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Zackary I ClevelandCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Cincinnati Children's Hospital Medical Center · USPhilips (Finland) · FI

Funding

UTE MRI to monitor CF lung disease and response to CFTR modulation in young childrenR01HL131012 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Raouf S. Amin, JASON C WOODS · 2016 to 2026
$6.8M
Imaging and Molecular Phenotyping of Cystic Fibrosis Lung DiseaseR01HL151588 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CLEVELAND, ZACKARY I, ZIADY, ASSEM G · 2021 to 2025
$3.9M
Validating Quantitative Magnetic Resonance Imaging Biomarkers of Idiopathic Pulmonary FibrosisR01HL143011 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CLEVELAND, ZACKARY I · 2019 to 2023
$3.7M
A Phase III Trial to Validate HP 129Xe MRI as a Functional Pulmonary Biomarker in Pediatric Lung DiseaseR44HL123299 · NHLBI · POLAREAN, INC. · PI EMAMI, KIARASH · 2017 to 2019
$3.0M
NHLBI NIH HHS R01 HL131012NHLBI NIH HHS R01 HL143011NHLBI NIH HHS R01 HL151588NHLBI NIH HHS R44 HL123299
6 · The paper itself

Abstract

rationaleHyperpolarized (HP)

methodsAn analytical expression for ADC uncertainty was derived from the Stejskal-Tanner equation and simplified Bloch equations appropriate for HP media. Parameters in the model were maximum b-value (b

resultsThe analytical model provides a lower bound on ADC uncertainty and predicts that decreased signal-to-noise ratio yields increases in relative uncertainty

conclusionsHP

Indexed as

Xenon IsotopesAdolescentAdultAge FactorsChildDiffusionDiffusion Magnetic Resonance ImagingFemaleHumansImage Processing, Computer-AssistedLungMaleSignal-To-Noise RatioUncertaintyYoung AdultXenon IsotopesADCb-valuediffusionhyperpolarized 129XelungSNR

Identifiers

PMID34729838
PMCPMC8828677
OpenAlexW3209422386

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.