Evidence map›Paper›PMID 34729693›Full record

ReviewCurrent osteoporosis reports2021

Mechanobiology of Bone Metastatic Cancer.

Blayne A Sarazin, Claire L Ihle, Philip Owens, Maureen E Lynch

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current osteoporosis reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Blayne A SarazinDepartment of Mechanical Engineering, University of Colorado, 427 UCB, Boulder, CO, 80309, USA.
Claire L IhleDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Philip OwensDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Maureen E LynchDepartment of Mechanical Engineering, University of Colorado, 427 UCB, Boulder, CO, 80309, USA. Maureen.Lynch@colorado.edu.ORCID 0000-0002-8247-2073

Funding

NRSA Training CoreTL1TR002533 · NCATS · UNIVERSITY OF COLORADO DENVER · PI CICUTTO, LISA · 2018 to 2022
$3.0M
BLRD VA IK2 BX002929NCATS NIH HHS TL1 TR002533
6 · The paper itself

Abstract

purpose of reviewIn this review, we provide an overview of what is currently known about the impacts of mechanical stimuli on metastatic tumor-induced bone disease (TIBD). Further, we focus on the role of the osteocyte, the skeleton's primary mechanosensory cell, which is central to the skeleton's mechanoresponse, sensing and integrating local mechanical stimuli, and then controlling the downstream remodeling balance as appropriate. RECENT

findingsExercise and controlled mechanical loading have anabolic effects on bone tissue in models of bone metastasis. They also have anti-tumorigenic properties, in part due to offsetting the vicious cycle of osteolytic bone loss as well as regulating inflammatory signals. The impacts of metastatic cancer on the mechanosensory function of osteocytes remains unclear. Increased mechanical stimuli are a potential method for mitigating TIBD.

Indexed as

BiophysicsBone RemodelingAnimalsBiomechanical PhenomenaBone NeoplasmsHumansMiceOsteocytesStress, MechanicalBone metastasisBone remodelingMechanical loadingOsteocytesTumor-induced bone disease

Identifiers

PMID34729693
PMCPMC11332992

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.