Evidence map›Paper›PMID 34729566›Full record

ArticlemedRxiv : the preprint server for health sciences2021

Limited impact of Delta variant’s mutations in the effectiveness of neutralization conferred by natural infection or COVID-19 vaccines in a Latino population.

Carlos A Sariol, Crisanta Serrano-Collazo, Edwin J Ortiz, Petraleigh Pantoja, Lorna Cruz, Teresa Arana, Dianne Atehortua, Christina Pabon-Carrero, Ana M Espino

Open access · greenAbstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Carlos A SariolDepartment of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, PR, USA.
Crisanta Serrano-CollazoUnit of Comparative Medicine, University of Puerto Rico-Medical Sciences Campus, San Juan, PR, USA.
Edwin J OrtizUnit of Comparative Medicine, University of Puerto Rico-Medical Sciences Campus, San Juan, PR, USA.
Petraleigh PantojaUnit of Comparative Medicine, University of Puerto Rico-Medical Sciences Campus, San Juan, PR, USA.
Lorna CruzDepartment of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, PR, USA.
Teresa AranaDepartment of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, PR, USA.
Dianne AtehortuaPuerto Rico Science, Technology and Research Trust, PR, USA.
Christina Pabon-CarreroPuerto Rico Science, Technology and Research Trust, PR, USA.
Ana M EspinoDepartment of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, PR, USA.
University of Puerto Rico, Medical Sciences Campus · PRConservation Trust of Puerto Rico · PR

Funding

SARS-CoV-2 correlates of protection in a Latino-origin populationU01CA260541 · NCI · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI BRIEN, JAMES D, LOPEZ, MARCOS · 2020 to 2024
$3.4M
NCI NIH HHS U01 CA260541
6 · The paper itself

Abstract

The SARS-CoV-2 pandemic has impacted public health systems all over the world. The Delta variant seems to possess enhanced transmissibility, but no clear evidence suggests it has increased virulence. Our data shows that pre-exposed individuals had similar neutralizing activity against the authentic COVID-19 strain and the Delta and Epsilon variants. After one vaccine dose, the neutralization capacity expands to all tested variants. Healthy vaccinated individuals showed a limited breadth of neutralization. One vaccine dose induced similar neutralizing antibodies against the Delta compared to the authentic strain. However, even after two doses, this capacity only expanded to the Epsilon variant.

Identifiers

PMID34729566
PMCPMC8562550
OpenAlexW3209416533

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.