Evidence map›Paper›PMID 34729556›Full record

ArticleResearch square2021

COVID-19 induces neuroinflammation and loss of hippocampal neurogenesis.

Robyn Klein, Allison Soung, Cheick Sissoko, Anna Nordvig, Peter Canoll, Madeline Mariani, Xiaoping Jiang, Traci Bricker, James Goldman, Gorazd Rosoklija and 6 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 94 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Robyn KleinWashington University School of Medicine.
Allison SoungWashington University School of Medicine.
Cheick SissokoColumbia University.
Anna NordvigWeill Cornell Medicine.
Peter CanollColumbia University Medical Center.
Madeline MarianiColumbia University.
Xiaoping JiangWashington University School of Medicine.
Traci BrickerWashington University School of Medicine.
James GoldmanColumbia University.
Gorazd RosoklijaColumbia University.
Victoria ArangoColumbia University.
Mark UnderwoodColumbia University.
J John MannORCID 0000-0002-0265-6586
Adrianus BoonWashington University.ORCID 0000-0002-4700-8224
Andrew DowrkColumbia University.
Maura BoldriniColumbia University.
Cornell University · USColumbia University · US

Funding

Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Miguel Arce · 2020 to 2026
$30.1M
Suicidal Behavior: Aggression Subtypes, Childhood Adversity and Stress ResponseP50MH090964 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MANN, JOSEPH JOHN · 2013 to 2022
$23.6M
Emerging infections: surveillance, epidemiology and pathogenesisU01AI151810 · NIAID · WASHINGTON UNIVERSITY · PI Adrianus CM Boon, DAVID WANG · 2020 to 2026
$10.0M
POSTMORTEM NEUROCHEMICAL STUDIES IN SUICIDER01MH040210 · NIMH · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI UNDERWOOD, MARK D · 1985 to 2016
$7.0M
Effect of Major Depression and antidepressants on human neurogenesisR01MH083862 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BOLDRINI, MAURA, HEN, RENE · 2009 to 2018
$5.4M
Golgi Studies of SchizophreniaR01MH064168 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI DWORK, ANDREW J · 2001 to 2013
$4.3M
Research Program Award (R35 Clinical Trial Optional) - Dr. Robyn Klein NINDSR35NS122310 · NINDS · WASHINGTON UNIVERSITY · PI CAIN, MATTHEW D · 2021 to 2024
$3.7M
Building Schizophrenia Research in MacedoniaR01MH098786 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DWORK, ANDREW J, ROSOKLIJA, GORAZD B. · 2012 to 2016
$2.2M
The Neuropathology of SUDEP : The central autonomic network, Serotonin and adenosineU01NS090415 · NINDS · UNIVERSITY COLLEGE LONDON · PI BOLDRINI, MAURA, DEVINSKY, ORRIN · 2014 to 2018
$2.0M
Application of Advanced Quantitative Methods to Schizophrenia ResearchR01MH125030 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI DWORK, ANDREW J, KOCAREV, LJUPCHO · 2021 to 2023
$1.7M
Hippocampal circuit plasticity in human normal aging and Alzheimer's DiseaseR56AG063372 · NIA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BOLDRINI, MAURA · 2020 to 2020
$760k
How the Novel Coronavirus Attacks the BrainR21AI164769 · NIAID · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BOLDRINI, MAURA · 2021 to 2022
$442k
NIAID NIH HHS R21 AI164769NIAID NIH HHS U01 AI151810NIA NIH HHS P30 AG066462NIA NIH HHS R56 AG063372NIMH NIH HHS P50 MH090964NIMH NIH HHS R01 MH040210NIMH NIH HHS R01 MH064168NIMH NIH HHS R01 MH083862NIMH NIH HHS R01 MH098786NIMH NIH HHS R01 MH125030NINDS NIH HHS R35 NS122310NINDS NIH HHS U01 NS090415
6 · The paper itself

Abstract

Infection with the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is associated with onset of neurological and psychiatric symptoms during and after the acute phase of illness

Identifiers

PMID34729556
PMCPMC8562542
OpenAlexW3210183886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.