Evidence map›Paper›PMID 34729540›Full record

ArticleJournal of photochemistry and photobiology2021

Rapid inactivation of SARS-CoV-2 with LED irradiation of visible spectrum wavelengths.

Riccardo De Santis, Vincenzo Luca, Jonas Näslund, Rosina K Ehmann, Marta De Angelis, Eva Lundmark, Lucia Nencioni, Giovanni Faggioni, Silvia Fillo, Donatella Amatore and 10 more

Abstract read
In one paragraph

Article in Journal of photochemistry and photobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The Wavelength-Based Inactivation Effects of a Light-Emitting Diode Module on Indoor Microorganisms.International journal of environmental research and public health · 2022
    Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Riccardo De SantisScientific Department, Army Medical Center, Rome, Italy.
Vincenzo LucaScientific Department, Army Medical Center, Rome, Italy.
Jonas NäslundDepartment of CBRN Protection and Security, Swedish Defence Research Agency (FOI), Umeå, Sweden.
Rosina K EhmannSection Viral and Intracellular Pathogens, Bundeswehr Institute of Microbiology, Munich, Germany.
Marta De AngelisDepartment of Public Health and Infectious Diseases, Laboratory Affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, "Sapienza" University of Rome, Italy.
Eva LundmarkDepartment of CBRN Protection and Security, Swedish Defence Research Agency (FOI), Umeå, Sweden.
Lucia NencioniDepartment of Public Health and Infectious Diseases, Laboratory Affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, "Sapienza" University of Rome, Italy.
Giovanni FaggioniScientific Department, Army Medical Center, Rome, Italy.
Silvia FilloScientific Department, Army Medical Center, Rome, Italy.
Donatella AmatoreScientific Department, Army Medical Center, Rome, Italy.
Elisa RegalbutoScientific Department, Army Medical Center, Rome, Italy.
Filippo MolinariScientific Department, Army Medical Center, Rome, Italy.
Giancarlo PetralitoScientific Department, Army Medical Center, Rome, Italy.
Roman WölfelSection Viral and Intracellular Pathogens, Bundeswehr Institute of Microbiology, Munich, Germany.
Paola StefanelliDepartment of Infectious Disease, National Institute of Health, Rome, Italy.
Gianni RezzaDepartment of Infectious Disease, National Institute of Health, Rome, Italy.
Anna Teresa PalamaraDepartment of Public Health and Infectious Diseases, Laboratory Affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, "Sapienza" University of Rome, Italy.
Markus AntwerpenSection Viral and Intracellular Pathogens, Bundeswehr Institute of Microbiology, Munich, Germany.
Mats ForsmanDepartment of CBRN Protection and Security, Swedish Defence Research Agency (FOI), Umeå, Sweden.
Florigio ListaScientific Department, Army Medical Center, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Difficulty in controlling SARS-CoV-2 transmission made the ability to inactivate viruses in aerosols and fomites to be an important and attractive risk reduction measure. Evidence that light frequencies have the ability to inhibit microorganisms has already been reported by many studies which, however, focused on ultraviolet (UV) wavelengths, which are known to induce potential injury in humans. In the present study, the effect on suspensions of SARS-CoV-2 of a Light Emitting Diode (LED) device capable of radiating frequencies in the non-hazardous visible light spectrum (VIS) was investigated. In order to evaluate the efficiency of viral inactivation, plaque assay and western blot of viral proteins were performed. The observed results showed a significant reduction in infectious particles that had been exposed to the LED irradiation of visible light. Furthermore, the analysis of the intracellular expression of viral proteins confirmed the inactivating effect of this irradiation technology. This

Indexed as

COVID-19InactivationLED irradiationSARS-CoV-2

Identifiers

PMID34729540
PMCPMC8552801

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.