Evidence map›Paper›PMID 34729379›Full record

ArticleMolecular therapy. Methods & clinical development2021

Jingying Guo, Xiaobo Ma, Jennifer M Skidmore, Jelka Cimerman, Diane M Prieskorn, Lisa A Beyer, Donald L Swiderski, David F Dolan, Donna M Martin, Yehoash Raphael

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 44 citations in OpenAlex.

  1. Recent Progress in Mechanism-Based Therapies forInternational journal of molecular sciences · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Treating Hearing Loss: From Cochlear Implantation to Gene Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  6. Article
  7. Review
  8. IsMedComm · 2025
    Article
  9. Article
  10. Combined AAV-mediated specific Gjb2 expression restores hearing in DFNB1 mouse models.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  11. Novel AAV-based GJB2 gene therapy restores hearing function.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. AAV-mediated Gene Therapy for Hereditary Deafness: Progress and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Jingying GuoKresge Hearing Research Institute, Otolaryngology, Head and Neck Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Xiaobo MaDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Jennifer M SkidmoreDepartment of Pediatrics, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Jelka CimermanDepartment of Pediatrics, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Diane M PrieskornKresge Hearing Research Institute, Otolaryngology, Head and Neck Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Lisa A BeyerKresge Hearing Research Institute, Otolaryngology, Head and Neck Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Donald L SwiderskiKresge Hearing Research Institute, Otolaryngology, Head and Neck Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
David F DolanKresge Hearing Research Institute, Otolaryngology, Head and Neck Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Donna M MartinDepartment of Pediatrics, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Yehoash RaphaelKresge Hearing Research Institute, Otolaryngology, Head and Neck Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Michigan Medicine · USBeijing Tongren Hospital · CNCapital Medical University · CN

Funding

Exploration of Connexin26 Genotypes, Phenotypes, and Gene ReplacementR01DC014456 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARTIN, DONNA M., RAPHAEL, YEHOASH · 2016 to 2020
$2.5M
NIDCD NIH HHS R01 DC014456
6 · The paper itself

Abstract

Pathogenic variants in

Indexed as

AAV-Anc80L65 gene therapycochlear GJB-2connexin 26DFNB1 deafnessgap junctionhearing lossinner hair celltransgenic mouseviral vector

Identifiers

PMID34729379
PMCPMC8531464
OpenAlexW3203574662

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.